ID   HBX14_DICDI             Reviewed;         455 AA.
AC   Q54H69;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox protein 14;
DE            Short=DdHbx-14;
GN   Name=hbx14; ORFNames=DDB_G0289677;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AAFI02000148; EAL62550.1; -; Genomic_DNA.
DR   RefSeq; XP_636049.1; XM_630957.1.
DR   AlphaFoldDB; Q54H69; -.
DR   SMR; Q54H69; -.
DR   PaxDb; Q54H69; -.
DR   EnsemblProtists; EAL62550; EAL62550; DDB_G0289677.
DR   GeneID; 8627259; -.
DR   KEGG; ddi:DDB_G0289677; -.
DR   dictyBase; DDB_G0289677; hbx14.
DR   HOGENOM; CLU_601919_0_0_1; -.
DR   InParanoid; Q54H69; -.
DR   OMA; VICFNEM; -.
DR   PRO; PR:Q54H69; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..455
FT                   /note="Homeobox protein 14"
FT                   /id="PRO_0000388797"
FT   DNA_BIND        310..369
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        372..431
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  50289 MW;  DD637E8C3B9646D8 CRC64;
     MNHNNNNYDF DNKNNSIGGG GGSSSRSSSS RSSNRSSSGS SGGSGSNSSS SINNIINSDK
     DFITERKQTK SPPLTLPNIK TTTTTTTTTT TTTTTTTKNE NISSSESENS SSRVESPNCN
     KKVKKTKTIT ISPTGYNINS KDDINKFTTY GYTNEKSNAR RDPKWITDII ERYNRLKSES
     PNNNYNGSSN NNNNINNINN NSNNTTSPCQ SPSSNTATIT SISSPTSSSS SLSSPSPSFS
     INNIVNQDVD GCDRMNYTLL SQNNNNNNNN NYNNNNNNNN NNNNNNNNTN TNNNGDECIV
     KPISLIQNKK SGQRSLKTKE HKEILEALYR VTLYPTSEET KIISQILGMT FGQVKSSFRH
     RREKLSKSGL FSYAKNLKNC GKCTVPLDNF FENCKYLTTK ETEEFAAAYD VSFEQIKNYF
     KGKRAILNKL SSKANQDNDN NNNNENNDDS YSDEG