ANDP_DROYA
ID ANDP_DROYA Reviewed; 57 AA.
AC Q8WPA1; B4PLU4; Q8WP55; Q8WSU9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Andropin;
DE Flags: Precursor;
GN Name=Anp; ORFNames=GE10865;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-22; MET-53 AND
RP SER-LYS-GLU-56 INS.
RC STRAIN=Y-0, Y-1, Y-2, Y-3, and Y-4;
RX PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT "Rapid evolution of the male-specific antibacterial protein andropin gene
RT in Drosophila.";
RL J. Mol. Evol. 54:665-670(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC positive bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC -!- INDUCTION: In response to mating.
CC -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
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DR EMBL; AB047043; BAB78548.1; -; Genomic_DNA.
DR EMBL; AB047051; BAB78556.1; -; Genomic_DNA.
DR EMBL; AB047052; BAB78557.1; -; Genomic_DNA.
DR EMBL; AB047053; BAB78558.1; -; Genomic_DNA.
DR EMBL; AB047054; BAB78559.1; -; Genomic_DNA.
DR EMBL; CM000160; EDW99081.1; -; Genomic_DNA.
DR RefSeq; XP_002099369.1; XM_002099333.2.
DR AlphaFoldDB; Q8WPA1; -.
DR SMR; Q8WPA1; -.
DR EnsemblMetazoa; FBtr0257383; FBpp0255875; FBgn0046894.
DR GeneID; 6538863; -.
DR KEGG; dya:Dyak_GE10865; -.
DR HOGENOM; CLU_2998613_0_0_1; -.
DR OMA; VETALHN; -.
DR OrthoDB; 1890984at2759; -.
DR PhylomeDB; Q8WPA1; -.
DR Proteomes; UP000002282; Chromosome 3R.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006962; P:male-specific antibacterial humoral response; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..57
FT /note="Andropin"
FT /id="PRO_0000004957"
FT VARIANT 22
FT /note="N -> D (in strain: Y-2)"
FT /evidence="ECO:0000269|PubMed:11965438"
FT VARIANT 53
FT /note="L -> M (in strain: Y-0 and Y-1)"
FT /evidence="ECO:0000269|PubMed:11965438"
FT VARIANT 56
FT /note="P -> PSKE (in strain: Y-0 and Y-1)"
SQ SEQUENCE 57 AA; 6227 MW; D3AA395A39B4C238 CRC64;
MKYFSVLVVL TLILAISVGQ SNAIFVDVLD NVETALHNAA KAGFKLIKPI EKLIMPK
