HBX2_DICDI
ID HBX2_DICDI Reviewed; 942 AA.
AC Q869W0; O43989; Q554G5;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Homeobox protein 2;
DE Short=DdHbx-2;
GN Name=hbx2; ORFNames=DDB_G0275173;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 409-942, DEVELOPMENTAL STAGE, DISRUPTION
RP PHENOTYPE, AND FUNCTION.
RC STRAIN=AX3-1;
RX PubMed=9486804; DOI=10.1242/dev.125.2.313;
RA Han Z., Firtel R.A.;
RT "The homeobox-containing gene Wariai regulates anterior-posterior
RT patterning and cell-type homeostasis in Dictyostelium.";
RL Development 125:313-325(1998).
CC -!- FUNCTION: Putative transcription factor that may potentiate the
CC function of warA. {ECO:0000269|PubMed:9486804}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Developmentally regulated and preferentially
CC expressed starting at the mound stage in response to cAMP. Expression
CC seems to require the transcription factor gbfA.
CC {ECO:0000269|PubMed:9486804}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Hbx2 and warA double
CC mutants form fruiting bodies with an enlarged basal disk and lower
CC portion of the stalk and the anterior of slugs is not as cylindrical as
CC that of wild-type slugs. {ECO:0000269|PubMed:9486804}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB92246.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000013; EAL69867.1; -; Genomic_DNA.
DR EMBL; AF036171; AAB92246.1; ALT_SEQ; mRNA.
DR RefSeq; XP_643746.1; XM_638654.1.
DR AlphaFoldDB; Q869W0; -.
DR SMR; Q869W0; -.
DR STRING; 44689.DDB0185105; -.
DR PaxDb; Q869W0; -.
DR PRIDE; Q869W0; -.
DR EnsemblProtists; EAL69867; EAL69867; DDB_G0275173.
DR GeneID; 8619790; -.
DR KEGG; ddi:DDB_G0275173; -.
DR dictyBase; DDB_G0275173; hbx2.
DR eggNOG; ENOG502RSNE; Eukaryota.
DR HOGENOM; CLU_311784_0_0_1; -.
DR InParanoid; Q869W0; -.
DR OMA; IMLNTHE; -.
DR PRO; PR:Q869W0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..942
FT /note="Homeobox protein 2"
FT /id="PRO_0000388786"
FT DNA_BIND 485..544
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 32..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 835..865
FT /evidence="ECO:0000255"
FT COMPBIAS 161..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 932
FT /note="R -> C (in Ref. 3; AAB92246)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 942 AA; 107111 MW; 33A69BA86146A493 CRC64;
MNIGSLLHSS MLGKQFQSNQ SQQEVVSNNI AECNENNNNN NNNNNNNNNS NNNNNNNNNN
NNNNNNNNNN NNDNNNNSNN NKININESSQ SITETVRSPY SSPSSSISSP SRSPSPNSPA
SSSPIHSPIP NTNFKQSGEY QSIPSPQNIH GLNKKVKVDM LESPNSSNSS PSFSSNMSPS
SSNSPRHRSN STSNNKSLLQ YQFNQSNQSP SFSPLRNNKN NNNINNNNNN NNNNNNNNNN
NNNQSPSMNG SPSSNLSKSN SGIPPLQLQA PSNTSSPQLL SPNHNQQRIS PNRYLNGGNN
NHNNNNNNNN NNNNNNNNNN NNNNNNHNNH NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNINNNNINN NNHNYNHNQN HNHNHNYNNN NQNNQNNNND DNFSPSHSPN
LSPSNYNSSP THYGNNNNDT PKRSHASYKN NNNNNNNNNN SNSSFDEYQP QQKVSRSNSP
NNDKEKKRRT RLKKEQADIL KTFFDNDDYP TKDDKETLAN RLGMSYCAVT TWFSNKRQEK
KRRGDVAPVQ TGGRRVPIDD EDDYENRNGD NSPSRNQGGA IELLKNSSSG LTPILESLNV
KQQNNINFFK NNNMDNNNKN VPHLSLSNNN NNNNNNNNNN NNNNNNNNNN NRNRNNNNIY
NNNNNNNNNN SNNRGKNFSD SGSSDSDSEL NRHNNNNNNN SNNYNNGNSN SNNNRNNNNN
YNYNNYINNN NYNNNNNRQH CDDEEEDEQY FNNNNNNNNN NNNNRISDSS DDQYFSDDTN
NNNDNYNNGN NNYNNNNNNN NFNNNYMNNY NNNYNNNNYN NNNSYNNSNG NNNFNNNNNN
NNQNNNNNNN NNQYNNNNKN YLNNIPSSKK HQLQGNYERR NSLPNSQIQN NFNGDNNNNN
NNKNNNNNNQ NNNGNGNNNN NNNNDNNIYK RRHSMDDDCQ QN
