HBX4_DICDI
ID HBX4_DICDI Reviewed; 740 AA.
AC Q86IH1; Q559C6;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Homeobox protein 4;
DE Short=DdHbx-4;
GN Name=hbx4; ORFNames=DDB_G0272967;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AAFI02000008; EAL71121.1; -; Genomic_DNA.
DR RefSeq; XP_644890.1; XM_639798.1.
DR AlphaFoldDB; Q86IH1; -.
DR SMR; Q86IH1; -.
DR STRING; 44689.DDB0220484; -.
DR PaxDb; Q86IH1; -.
DR EnsemblProtists; EAL71121; EAL71121; DDB_G0272967.
DR GeneID; 8618569; -.
DR KEGG; ddi:DDB_G0272967; -.
DR dictyBase; DDB_G0272967; hbx4.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_375280_0_0_1; -.
DR InParanoid; Q86IH1; -.
DR PRO; PR:Q86IH1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:dictyBase.
DR GO; GO:1901262; P:negative regulation of sorocarp spore cell differentiation; IMP:dictyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0031153; P:slug development involved in sorocarp development; IMP:dictyBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..740
FT /note="Homeobox protein 4"
FT /id="PRO_0000388788"
FT DNA_BIND 605..667
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 254..287
FT /evidence="ECO:0000255"
FT COILED 472..500
FT /evidence="ECO:0000255"
FT COMPBIAS 179..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84487 MW; 7AF5A04B780394C5 CRC64;
MNTVEENNTK ITDNNNNNNN NNNNNNNNNN NNKNNDGENL SQQLIDSNNK KLRSPIQVYF
DSDVSSCSLQ SQSSPQQLPT QQPIQQQINN IFNHFLPQNQ APLLQAQNQQ PINNINQVSN
FQIQPIPLTF QLPNNINTNT NNTNMINNVQ QFQNNFLNNN DFSLTDPVPS PFVLFNNNNN
NNNNNNNNNN NNINNFHHNN INNNFDNNNS NYNTINTHPN NTNNNSSNIN QIQSNIYPQQ
NLHNPFLPIH NNNNINNNNI NKNNNNYNNN NNNKNNNNNN NNNNNNNNPQ LFSMEPPNGF
NHSTTDNTSS VSSVPSNKKK SSKTKQKSKP LTIQQQQQHK SNYHQQPNQN SQHLQSKPNS
PILISSPLNS QQNSSPPQPS PTQSFLSPPQ YSQSPQNNNF NNNNNNISNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNINNSTNN NNNNSNTNNN TNTNTNNNNN
KNNNNNNNNE IENNNNEELI LLWYNSIIKN IIVDENHFKI ENQFNKENGY LVFKQLFKNH
FGSIGTIGKE MAEYIQLHCE VMNEITELSK FHFQSIDNFY NNYIRIINGY SLIPAKDSGA
TIKARPKKGA KLSKESKDIL ENWIKNHIAH PYPTNDEKEQ LQRQTGLTPN QISNWFINTR
RRKVPTLCDE AGIITNSNVM PQMTINNNNN NGGNSNFKNN NNNTITTTST SNNNNNNNNN
NHNEMECDDG ENEESSEYDD
