HBX5_DICDI
ID HBX5_DICDI Reviewed; 1723 AA.
AC Q557C9; Q8T248;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Homeobox protein 5;
DE Short=DdHbx-5;
GN Name=hbx5-1; ORFNames=DDB_G0273127;
GN and
GN Name=hbx5-2; ORFNames=DDB_G0273645;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70513.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70781.1; -; Genomic_DNA.
DR RefSeq; XP_644439.1; XM_639347.1.
DR RefSeq; XP_644811.1; XM_639719.1.
DR AlphaFoldDB; Q557C9; -.
DR SMR; Q557C9; -.
DR STRING; 44689.DDB0220481; -.
DR PaxDb; Q557C9; -.
DR EnsemblProtists; EAL70513; EAL70513; DDB_G0273645.
DR EnsemblProtists; EAL70781; EAL70781; DDB_G0273127.
DR GeneID; 8618913; -.
DR GeneID; 8619064; -.
DR KEGG; ddi:DDB_G0273127; -.
DR KEGG; ddi:DDB_G0273645; -.
DR dictyBase; DDB_G0273127; hbx5-1.
DR dictyBase; DDB_G0273645; hbx5-2.
DR eggNOG; ENOG502REC7; Eukaryota.
DR HOGENOM; CLU_240221_0_0_1; -.
DR InParanoid; Q557C9; -.
DR PRO; PR:Q557C9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1723
FT /note="Homeobox protein 5"
FT /id="PRO_0000388789"
FT DOMAIN 1553..1588
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DNA_BIND 1543..1607
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 36..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1598..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1661..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 300..351
FT /evidence="ECO:0000255"
FT COILED 1193..1270
FT /evidence="ECO:0000255"
FT COILED 1431..1464
FT /evidence="ECO:0000255"
FT COILED 1632..1702
FT /evidence="ECO:0000255"
FT COMPBIAS 36..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 188913 MW; F68A3B702B3FEB95 CRC64;
METIVNNQNN GQQNTVPTQS FSSSVYMNYD FFDSQQLQQP QHQPQHYQQQ DSFVSPNLDN
NNPQIHVQSN NYNQNGFVGY NNSNNNNNNN QHMNNQYSNS FHNNNSSGFM AFQNNSSNFN
NQNNNNSNNN NNNNNINSYD YNNSNNNNYN NNNNTHSNNS NNNNNNNNSN YWNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NSNNNNNNNN NNNHHHHHHQ QQSQPTSPYN NPIQHNPNDM
KFNGQHNPFN GNQMVMDNNN NNNNNNNSNV FNSNSNSNVF NSNSGSFLQI NNNNGSFSSY
NNNNNNNNNN NSNSNNNNNN NNNNNNNNNN NNNNNNNNNN NNNSNNNNNN QFSQSYDSTL
GNNRFSSMMG QPIQQQQSPP QQQQQQSFIQ SSPQAIPASN CNGNGSTSSS TSPLSPTLIG
SAPGTPTSML ATTLFGFNLS SSPTSSPSSP VKKGKSQSAL ALSSSGGSGG SSGRKKPQKH
DSMSSITNTN LKSTQASTLK ESKRSNSSPN LKKQMQLQQL QQQQKLNENG TLIPPLPFAS
ISENITNNNN NNNNNNNNNN NNNNNNNITN NPLSGSMEFP NSNNINQSSD SINGEFNIGQ
PESPKMYNSS PSPPPNATST TKGGKKSKKS LHISTTQQSP SLNGSTGGSM LTPTMSGLSL
SGGGSGGGFS PLISPTGTTS NKDLQSSPSP SPLLKSMSMG KLDLQDSIDS MSSPLSPNSS
LSSSNGLLPP PPNSNNMNSS GGIPTPSTPT SPPPLTHHIN IFSNLEFVKQ LKDHLLPNDF
KPEEHALERN LLRFQQFVKT LAEPLQRDVV TSMFELSVDA QLQYGSNLDN DNLSALMLFR
RKILNFNLFR MMMLNDPNSF IPLPSPFPIQ TTTISSNGTI VNPTNVNNNN INNNNNNNNN
NNNNNNNNNN NNNNNNNNNT TTTTTTTTSA NTVQSGTTSN SNLVFQQTSN SNTLSPSQQQ
QQQTQQQQSI NGSSTGSLSD AQYQDLGIHL DTSSANSGCG INVSIGSSIG GGGGGSSLNG
SNLNGSSSIS GSISGGSSNG GGQFIMSPQF SLDGAYQQQQ PSSYNINNEM ELAEKDEDEI
FNNNNKDNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNSSS INSNINNVNN CNINNNSNSN
NGSINSPRPS TPTTLNSSGK RSKKIYRGDS FGAGNDISTG LMASSDQIIP PPQQQQHQQL
VNNNNNNMNN SENNILLADS NKGLSVSLGS LPTNTPSSME IEQQQQQQQQ QQQQQQQQHL
NQQQILHQQL HHHLSSSLGG AQFTNIQQQQ QQQSGNIFYN SPYNSSQVYM NPYGTSITNT
SLAGPSTTSS AMQHMITNMT SSNIIVNNQN NNNNDQNNNN NNNNNNNSTT NSNVNNNNNT
TNTPSSPPQP NNCTPTQTSI ITSNGVVVPS LQMRGTITNP PPVLPTPDTL VLQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQETPHTPTS NSISSPRSSP VHQQSPSNTN TTTTSTTTIR
HSAVTQLSFA GLHNQQVSPI SPRSPRSPHG TSGDYNDGSQ SPSSRRKNRF TDFQIKRMND
CFENLDKNNN GKFTSEEICQ IATELGLTDQ QVRVFFQNKR ARSRPSPRGQ PTNPLTSSTN
NGNNSNLALQ HLQQQHLQQV QQQQQQLLQL QQQQQQQQQQ LHQQSANTTP QLNSMNPNSI
NYNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNIINNNITT INE
