ID   HBX6_DICDI              Reviewed;         516 AA.
AC   Q54ZP8;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Homeobox protein 6;
DE            Short=DdHbx-6;
GN   Name=hbx6; ORFNames=DDB_G0277505;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AAFI02000020; EAL68715.1; -; Genomic_DNA.
DR   RefSeq; XP_642594.1; XM_637502.1.
DR   AlphaFoldDB; Q54ZP8; -.
DR   SMR; Q54ZP8; -.
DR   STRING; 44689.DDB0220482; -.
DR   PaxDb; Q54ZP8; -.
DR   EnsemblProtists; EAL68715; EAL68715; DDB_G0277505.
DR   GeneID; 8621011; -.
DR   KEGG; ddi:DDB_G0277505; -.
DR   dictyBase; DDB_G0277505; hbx6.
DR   eggNOG; ENOG502SYC5; Eukaryota.
DR   HOGENOM; CLU_601919_0_0_1; -.
DR   InParanoid; Q54ZP8; -.
DR   PRO; PR:Q54ZP8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 2.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS50071; HOMEOBOX_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..516
FT                   /note="Homeobox protein 6"
FT                   /id="PRO_0000388790"
FT   DNA_BIND        362..421
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        424..483
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          22..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..510
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   516 AA;  56946 MW;  C61C7BE687791ABB CRC64;
     MDKCVITGHH FSVENMNHNN NNYDFDNKNN SIGGGGGGGG SSSSRSSSSR SSSNRSSSGS
     SGGSGSNSSS SINNIINSDN DFKTERKQTK SPPLTLPNIK TTTTTTTTTT TTTTTTTKNE
     NISSSESENS SSRVGSPNCN KKVKKTKTIT ISPTGYNINS KDDINKFTTY GYTNEKSNAR
     RDPKWINDII ERYNRLKSES LNNNYNGSSS NNNNINNINN NSNNTTSPCQ SPSSNTATIT
     SISSPTSSSS SLSSPSFSIN NIVNQDVDEN DGCDRMNYTL LSQNNNNNNN NNNNNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN TNTNNNGDEC IVKPISLIQN
     KKSGQRSLKT KEHKEILEAL YRVTLYPTSE ETKTISQILG MTFGQVKSSF RHRREKLSKS
     GLFSYAKNLK NCGKSTAPLD NFFENCKYLT TKETEEFAAA YDVSFEQIKN YFKGKRAKLN
     KLSSKAIQDK DNQDNDNNNS NNNENNDDSY SDEGLF