ID   HBX8_DICDI              Reviewed;         327 AA.
AC   Q54X22;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Homeobox protein 8;
DE            Short=DdHbx-8;
GN   Name=hbx8; ORFNames=DDB_G0279257;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AAFI02000030; EAL67777.1; -; Genomic_DNA.
DR   RefSeq; XP_641755.1; XM_636663.1.
DR   AlphaFoldDB; Q54X22; -.
DR   SMR; Q54X22; -.
DR   PaxDb; Q54X22; -.
DR   EnsemblProtists; EAL67777; EAL67777; DDB_G0279257.
DR   GeneID; 8621953; -.
DR   KEGG; ddi:DDB_G0279257; -.
DR   dictyBase; DDB_G0279257; hbx8.
DR   eggNOG; ENOG502RHY1; Eukaryota.
DR   HOGENOM; CLU_851066_0_0_1; -.
DR   InParanoid; Q54X22; -.
DR   PRO; PR:Q54X22; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS50071; HOMEOBOX_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..327
FT                   /note="Homeobox protein 8"
FT                   /id="PRO_0000388792"
FT   DNA_BIND        169..228
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        232..291
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          129..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  39115 MW;  F9CC246A086BED9E CRC64;
     MENNNNKQNV KNRNNLKIKF KEDFCNDSTE VEQQPPSNLS SPTSYIQGNK LYFNFYDNIS
     NNVSNNYSYN CNNKNNNNNN NKNDNGNYYF FNSENILKNN LQQNETKNSC HHLNQSYNKI
     EFQNNYQSDY QSDNQSDCQS DNQSDNQSDN QSEIQNNKDG NESVVPPKVK KTRSRKTKEH
     KDQLENLFNS NPFPDAIEKE IIAYQFDMSV EQIVTWFKHK RENLKKAQHL EYKQNSTKKF
     TKTTKELYVY FENYPFPQEE RVEYFAKSYH TSNEKILNWF SKKRYSLRKT HSFIYDKGCG
     LYKYENSNFN FCSHFPEKKF DINFINN