HBX9_DICDI
ID HBX9_DICDI Reviewed; 639 AA.
AC Q54VB4;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Homeobox protein 9;
DE Short=DdHbx-9;
GN Name=hbx9; ORFNames=DDB_G0280473;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AAFI02000036; EAL67215.1; -; Genomic_DNA.
DR RefSeq; XP_641195.1; XM_636103.1.
DR AlphaFoldDB; Q54VB4; -.
DR SMR; Q54VB4; -.
DR STRING; 44689.DDB0220485; -.
DR PaxDb; Q54VB4; -.
DR EnsemblProtists; EAL67215; EAL67215; DDB_G0280473.
DR GeneID; 8622576; -.
DR KEGG; ddi:DDB_G0280473; -.
DR dictyBase; DDB_G0280473; hbx9.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_428605_0_0_1; -.
DR InParanoid; Q54VB4; -.
DR PRO; PR:Q54VB4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IMP:dictyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..639
FT /note="Homeobox protein 9"
FT /id="PRO_0000388793"
FT DNA_BIND 559..621
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..109
FT /evidence="ECO:0000255"
FT COILED 152..184
FT /evidence="ECO:0000255"
FT COILED 230..296
FT /evidence="ECO:0000255"
FT COILED 365..396
FT /evidence="ECO:0000255"
FT COMPBIAS 355..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72026 MW; 4455A1630881CE89 CRC64;
MLNSYSPLQS PSSSITLPPL FHINNNNNNN NNNNNNNGHN NDKQNVNKLG LKLNINGYDS
GFSPFSPNHS IANNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNIQS PKNNNSNNNK
LNESCGSLNS SNDNNFNSGN DDNSLKRVRV FSNQNQNQNQ NQNQNQNQNQ NQNQNQNQNQ
KDSWNIHFGE IVNIVLELES VLSCKNENIN QINQIKSSEK SMRSALYKKE IEILELKDKL
NNSSATFNSL KVIQPIKLEK SPRTLNNSSD SISENINNNN NNNNNNNNNN NNNINESNIN
TSPTHELSGS SGTLGGYSKS HILSILDDLD SESSNISSDS EDDEQPRKVP RDLNYKPNNN
INYANNNNNN NNNNNNNNHN NNINNNNNNN NNNNNNSNNY HHSIGSITNS VNIKPSKDQT
SNDWAAATEA LLNLHTNKNN NNNNNNNNNN NNNYHSNNNN YSNSPNTTPP YQNSNQQFNN
NQPQSQQQQQ SQQQQQQQQQ YQNSINKNIT TTTNNNNNNL TSSSNNQAVV YGNTSPNQSS
ANGNNENVIG VPFTGSIVKR KKRGKLPGEA TSILKKWLFE HNMHPYPTEE EKVALANSTF
LSFNQINNWF TNARRRILPR QLDRKVFGSP LFSHFSITK
