ID   ANDR_BURCE              Reviewed;         318 AA.
AC   Q84BZ4;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Anthranilate 1,2-dioxygenase regulatory protein {ECO:0000303|PubMed:13129960};
DE   AltName: Full=HTH-type transcriptional regulator AndR;
GN   Name=andR {ECO:0000312|EMBL:AAO83638.1};
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAO83638.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 29424 / DBO1 {ECO:0000312|EMBL:AAO83638.1};
RX   PubMed=13129960; DOI=10.1128/jb.185.19.5871-5881.2003;
RA   Chang H.K., Mohseni P., Zylstra G.J.;
RT   "Characterization and regulation of the genes for a novel anthranilate 1,2-
RT   dioxygenase from Burkholderia cepacia DBO1.";
RL   J. Bacteriol. 185:5871-5881(2003).
CC   -!- FUNCTION: Involved in anthranilate degradation through activation of
CC       expression of the anthranilate 1,2-dioxygenase subunits.
CC       {ECO:0000269|PubMed:13129960}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene are unable to grow on
CC       anthranilate. {ECO:0000269|PubMed:13129960}.
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DR   EMBL; AY223539; AAO83638.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q84BZ4; -.
DR   SMR; Q84BZ4; -.
DR   STRING; 292.DM42_4277; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR035418; AraC-bd_2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF14525; AraC_binding_2; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; Aromatic hydrocarbons catabolism; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Anthranilate 1,2-dioxygenase regulatory protein"
FT                   /id="PRO_0000415164"
FT   DOMAIN          216..316
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        233..254
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250|UniProtKB:P0ACH5,
FT                   ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        283..306
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250|UniProtKB:P0ACH5,
FT                   ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   318 AA;  34911 MW;  11D8B3F2AF311257 CRC64;
     MSPTSFEPLA LRAHRLFESR DLDETRERIS RVMQPHALLP SGRMQGAAHM DFVRLGGLGI
     GTIAFGDAMR VQVDAVDGYY LLMFCLSGHA QVAAMGRRLG VDGQTGVLCA PGERFDAVLS
     ADCEQFVLRI DAATVGSLTG NPRATLDPVL HISDAALAAW HQQLMLVARS PALLARANAN
     PRVAAQLEHL LIDLLIEGHP PAAASMRHDP APGFLLRAQE FVNAHYAQPL QLADIVVAAN
     VPERTLRDAF LQFRGMSPMQ YLRATRLEHA RELLRRSQPE RRIADVALDC GFTHLGRFAI
     AYREKFGESP SETVGVRR