ID   HBZ_HTL1L               Reviewed;         208 AA.
AC   P0C747;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   23-FEB-2022, entry version 19.
DE   RecName: Full=HTLV-1 basic zipper factor;
DE            Short=HBZ;
GN   Name=HBZ;
OS   Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus.
OX   NCBI_TaxID=402046;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8419636; DOI=10.1128/jvi.67.2.1015-1023.1993;
RA   Gessain A., Boeri E., Yanagihara R., Gallo R.C., Franchini G.;
RT   "Complete nucleotide sequence of a highly divergent human T-cell leukemia
RT   (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and
RT   phylogenetic relationship to HTLV-I strains from other geographical
RT   regions.";
RL   J. Virol. 67:1015-1023(1993).
CC   -!- FUNCTION: Contributes to the regulation of viral RNA transcription by
CC       interacting with host proteins involved in transcriptional activation
CC       such as ATF4, or CREB1, and by inhibiting their activity. Additionally,
CC       HBZ suppresses host NF-kappa-B-driven transcription mediated by host
CC       RELA as well as transcription of some classical NF-kappa-B target
CC       genes, including IL8, IL2RA, IRF4, VCAM1, and VEGFA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host ATF4; this interaction inhibits viral RNA
CC       transcriptional activation by preventing ATF4 binding to Tax-responsive
CC       elements. Interacts with host CREB1; this interaction inhibits host
CC       CREB1 transcriptional activity. Interacts with host JUN, JUNB and JUND.
CC       Interacts with host EP300 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=HBZ;
CC         IsoId=P0C747-1; Sequence=Displayed;
CC       Name=HBZ-SI;
CC         IsoId=P0C747-2; Sequence=VSP_037727;
CC   -!- DOMAIN: Contains three nuclear localization signals NLS-1 and NLS-2,
CC       corresponding to two regions rich in basic amino acids, and NLS-3
CC       corresponding to its DNA-binding domain.
CC   -!- MISCELLANEOUS: While mRNA expression levels of HBZ-SI were similar to
CC       those of HBZ, HBZ-SI seems slightly more expressed at the protein level
CC       ex vivo.
CC   -!- SIMILARITY: Belongs to the HTLV-1 HBZ protein family. {ECO:0000305}.
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DR   EMBL; L02534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C747; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR026220; HTLV1ZIPPER.
DR   PRINTS; PR02097; HTLV1ZIPPER.
PE   3: Inferred from homology;
KW   Alternative splicing; DNA-binding; Host nucleus; Host-virus interaction.
FT   CHAIN           1..208
FT                   /note="HTLV-1 basic zipper factor"
FT                   /id="PRO_0000379887"
FT   REGION          59..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           86..91
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           115..119
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000250"
FT   MOTIF           136..140
FT                   /note="Nuclear localization signal 3"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        70..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..7
FT                   /note="MINFVFV -> MAAS (in isoform HBZ-SI)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037727"
SQ   SEQUENCE   208 AA;  25018 MW;  E7DE9118A7A1E067 CRC64;
     MINFVFVGPF RCLPVPCPED LLVEDLVDGL LSLEDELKDQ REEEESVLDG VLSLEEESRL
     RWGPVGEEAP PRGETHRDRQ RRAEEKRKRK REREKEEEKQ IAEFLKRKRE KEAWRRRRAE
     EKAADRARRK LEEEERRERK WRQTEQGAKQ RSARKEKMTE LGVDGYARQL ESEAESLEAE
     RGRLLQENDD LMGEVNYWQR RLEAMWSQ