ID   HCAB_PHOLL              Reviewed;         280 AA.
AC   Q7N4V7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE            EC=1.3.1.87 {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=CI-dihydrodiol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
DE   AltName: Full=PP-dihydrodiol dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01647};
GN   Name=hcaB {ECO:0000255|HAMAP-Rule:MF_01647}; OrderedLocusNames=plu2207;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and
CC       cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-
CC       dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid
CC       (DHCI), respectively. {ECO:0000255|HAMAP-Rule:MF_01647}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate +
CC         NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH;
CC         Xref=Rhea:RHEA:25062, ChEBI:CHEBI:15378, ChEBI:CHEBI:46951,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.3.1.87;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01647};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate
CC         + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH;
CC         Xref=Rhea:RHEA:25066, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58642, ChEBI:CHEBI:61451; EC=1.3.1.87;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01647};
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC       {ECO:0000255|HAMAP-Rule:MF_01647}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01647}.
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DR   EMBL; BX571866; CAE14500.1; -; Genomic_DNA.
DR   RefSeq; WP_011146459.1; NC_005126.1.
DR   AlphaFoldDB; Q7N4V7; -.
DR   SMR; Q7N4V7; -.
DR   STRING; 243265.plu2207; -.
DR   EnsemblBacteria; CAE14500; CAE14500; plu2207.
DR   GeneID; 24166432; -.
DR   KEGG; plu:plu2207; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_0_6; -.
DR   OMA; VFHINVK; -.
DR   OrthoDB; 1356861at2; -.
DR   BioCyc; PLUM243265:PLU_RS11020-MON; -.
DR   UniPathway; UPA00714; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0018498; F:2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019380; P:3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01647; HcaB; 1.
DR   InterPro; IPR023643; Dihydrodiol_DH_HcaB.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..280
FT                   /note="3-phenylpropionate-dihydrodiol/cinnamic acid-
FT                   dihydrodiol dehydrogenase"
FT                   /id="PRO_0000333763"
FT   ACT_SITE        156
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01647"
FT   BINDING         143
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01647"
SQ   SEQUENCE   280 AA;  29538 MW;  8623C46C17F45AEE CRC64;
     MSWIKDQVIL LTGGGSGLGL ALIERFIAEG AKVGVLELSA EKATALAHCF GNDICVIHGD
     VVSFEDNERA VAETVRCFGK LDCFVGNAGI WDHKISLLDA SPEQIDKGFD ELMGVNLKGY
     ILGAKAALPA LTASEGSMIF TLSNSSWFSG GGGVLYTASK HGAVGMIRQL AYELAPVIRV
     NGVAPCGMPS DLRGAASLSQ QDRCITDNLS LESLSAILPL QFIPQPKDFT GPYVMLASRA
     NNRTLTGVMI TADAGLSIRG IRQTTAGVMS PTKKESSDDR