HCAC_PHOLL
ID HCAC_PHOLL Reviewed; 105 AA.
AC Q7N4V8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit {ECO:0000255|HAMAP-Rule:MF_01650};
GN Name=hcaC {ECO:0000255|HAMAP-Rule:MF_01650}; OrderedLocusNames=plu2206;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- FUNCTION: Part of the multicomponent 3-phenylpropionate dioxygenase,
CC that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into
CC 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-
CC dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a
CC 2Fe-2S ferredoxin. {ECO:0000255|HAMAP-Rule:MF_01650}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01650};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01650};
CC -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC {ECO:0000255|HAMAP-Rule:MF_01650}.
CC -!- SUBUNIT: This dioxygenase system consists of four proteins: the two
CC subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin
CC (HcaC) and a ferredoxin reductase (HcaD). {ECO:0000255|HAMAP-
CC Rule:MF_01650}.
CC -!- SIMILARITY: Belongs to the bacterial ring-hydroxylating dioxygenase
CC ferredoxin component family. {ECO:0000255|HAMAP-Rule:MF_01650}.
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DR EMBL; BX571866; CAE14499.1; -; Genomic_DNA.
DR RefSeq; WP_011146458.1; NC_005126.1.
DR AlphaFoldDB; Q7N4V8; -.
DR SMR; Q7N4V8; -.
DR STRING; 243265.plu2206; -.
DR EnsemblBacteria; CAE14499; CAE14499; plu2206.
DR GeneID; 24166433; -.
DR KEGG; plu:plu2206; -.
DR eggNOG; COG2146; Bacteria.
DR HOGENOM; CLU_055690_5_0_6; -.
DR OMA; TLECWLH; -.
DR OrthoDB; 1681886at2; -.
DR BioCyc; PLUM243265:PLU_RS11015-MON; -.
DR UniPathway; UPA00714; -.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008695; F:3-phenylpropionate dioxygenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019380; P:3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.102.10.10; -; 1.
DR HAMAP; MF_01650; HcaC; 1.
DR InterPro; IPR023739; HcaC.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR Pfam; PF00355; Rieske; 1.
DR SUPFAM; SSF50022; SSF50022; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Aromatic hydrocarbons catabolism; Electron transport; Iron;
KW Iron-sulfur; Metal-binding; Reference proteome; Transport.
FT CHAIN 1..105
FT /note="3-phenylpropionate/cinnamic acid dioxygenase
FT ferredoxin subunit"
FT /id="PRO_0000333720"
FT DOMAIN 4..99
FT /note="Rieske"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01650"
FT BINDING 42
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01650"
FT BINDING 44
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01650"
FT BINDING 62
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01650"
FT BINDING 65
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01650"
SQ SEQUENCE 105 AA; 11536 MW; 8B6736D30D6714FB CRC64;
MSQLFVCTVE ELPDGGARKV EYTPDIALFH YDGEFFAVDD RCSHGNASIS EGYLEDNATV
ECPLHTASFC LRTGKALCLP ATDPLKTYPV VVKDGNIYIT VSEEQ
