HCAT_HAEIN
ID HCAT_HAEIN Reviewed; 388 AA.
AC P44629;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable 3-phenylpropionic acid transporter;
GN Name=hcaT; OrderedLocusNames=HI_0308;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Probable permease involved in the uptake of 3-phenylpropionic
CC acid. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Phenyl
CC propionate permease (PPP) (TC 2.A.1.27) family. {ECO:0000305}.
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DR EMBL; L42023; AAC21973.1; -; Genomic_DNA.
DR PIR; F64147; F64147.
DR RefSeq; NP_438475.1; NC_000907.1.
DR RefSeq; WP_005694357.1; NC_000907.1.
DR AlphaFoldDB; P44629; -.
DR SMR; P44629; -.
DR STRING; 71421.HI_0308; -.
DR EnsemblBacteria; AAC21973; AAC21973; HI_0308.
DR KEGG; hin:HI_0308; -.
DR PATRIC; fig|71421.8.peg.325; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_013133_6_0_6; -.
DR OMA; HGPYYTF; -.
DR PhylomeDB; P44629; -.
DR BioCyc; HINF71421:G1GJ1-326-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030395; F:lactose binding; IBA:GO_Central.
DR GO; GO:0015528; F:lactose:proton symporter activity; IBA:GO_Central.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR026032; HcaT.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF12832; MFS_1_like; 1.
DR PIRSF; PIRSF004925; HcaT; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00902; 2A0127; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..388
FT /note="Probable 3-phenylpropionic acid transporter"
FT /id="PRO_0000196190"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 5..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 32..37
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 38..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 67..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 71..96
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 97..100
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 101..119
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 120..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 131..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 154..156
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 157..176
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 177..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 211..230
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 231..234
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 235..259
FT /note="Helical; Name=8"
FT /evidence="ECO:0000250"
FT TOPO_DOM 260..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 270..289
FT /note="Helical; Name=9"
FT /evidence="ECO:0000250"
FT TOPO_DOM 290..292
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 293..315
FT /note="Helical; Name=10"
FT /evidence="ECO:0000250"
FT TOPO_DOM 316..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 327..354
FT /note="Helical; Name=11"
FT /evidence="ECO:0000250"
FT TOPO_DOM 355..357
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 358..378
FT /note="Helical; Name=12"
FT /evidence="ECO:0000250"
FT TOPO_DOM 379..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 388 AA; 43030 MW; 60A7258E1DC688D2 CRC64;
MQVRPFYWLA LSFLGYYCAY GVFLPFFPAW LKSQQYGEEM IGLVIGSAYI FRFAGGLFFS
SLIKKANHII IALRLLALAS AIIMAAMSLV AHNFWLLFIA IGLYASVNSA GMPIGDSLAS
TWQRQIGLDY GKVRLIGSAA FILGVVVFGG MIGWVGEQNI VWILTALLSF YTIIQLLKPT
IPPKDEIPED SVQNDVGFIA LLKNPMTLRV MIAVGLIQGS HAAYYVYSTI YWTSIGISVS
QTSLLWGIGV LAEIVLFFFS RRLFQNISIS VLLYISALAC VGRWAVIGYI EDFWLIFLLQ
LMHSLTYAVC HYAIVRYITT QPQSHIAKLQ GLYNGLSNGV LIAIFTAIAG MIYPTSPAMT
FVFMSIIAAA AFFVIPRKLN AFLIVQHK
