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HCDH1_CAEEL
ID   HCDH1_CAEEL             Reviewed;         298 AA.
AC   P34439;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1;
DE            EC=1.1.1.35;
GN   ORFNames=F54C8.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; Z22178; CAA80153.1; -; Genomic_DNA.
DR   PIR; S40743; S40743.
DR   RefSeq; NP_499075.1; NM_066674.1.
DR   PDB; 4J0E; X-ray; 1.60 A; A/B=1-298.
DR   PDB; 4J0F; X-ray; 2.20 A; A/B=1-298.
DR   PDBsum; 4J0E; -.
DR   PDBsum; 4J0F; -.
DR   AlphaFoldDB; P34439; -.
DR   SMR; P34439; -.
DR   BioGRID; 50969; 2.
DR   STRING; 6239.F54C8.1; -.
DR   EPD; P34439; -.
DR   PaxDb; P34439; -.
DR   PeptideAtlas; P34439; -.
DR   EnsemblMetazoa; F54C8.1.1; F54C8.1.1; WBGene00010035.
DR   EnsemblMetazoa; F54C8.1.2; F54C8.1.2; WBGene00010035.
DR   GeneID; 186222; -.
DR   KEGG; cel:CELE_F54C8.1; -.
DR   UCSC; F54C8.1; c. elegans.
DR   CTD; 186222; -.
DR   WormBase; F54C8.1; CE00187; WBGene00010035; -.
DR   eggNOG; KOG2304; Eukaryota.
DR   GeneTree; ENSGT00940000166803; -.
DR   HOGENOM; CLU_009834_2_0_1; -.
DR   InParanoid; P34439; -.
DR   OMA; CKLGFGH; -.
DR   OrthoDB; 938257at2759; -.
DR   PhylomeDB; P34439; -.
DR   BRENDA; 1.1.1.35; 1045.
DR   UniPathway; UPA00659; -.
DR   PRO; PR:P34439; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00010035; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Fatty acid metabolism; Lipid metabolism; Mitochondrion; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..298
FT                   /note="Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1"
FT                   /id="PRO_0000109253"
FT   SITE            153
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
FT   HELIX           2..5
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          13..17
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           21..32
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          36..40
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           44..64
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           69..80
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          83..87
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           89..93
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          97..101
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           107..120
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          126..129
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          132..134
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           136..139
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   TURN            140..142
FT                   /evidence="ECO:0007829|PDB:4J0F"
FT   HELIX           146..148
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          149..153
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   TURN            158..160
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          163..168
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           174..186
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          190..196
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   TURN            198..201
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           202..219
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           224..235
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           241..248
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           250..263
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          264..266
FT                   /evidence="ECO:0007829|PDB:4J0F"
FT   HELIX           268..270
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           274..281
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   HELIX           287..289
FT                   /evidence="ECO:0007829|PDB:4J0E"
FT   STRAND          291..295
FT                   /evidence="ECO:0007829|PDB:4J0E"
SQ   SEQUENCE   298 AA;  32492 MW;  D8C2BE57823445B4 CRC64;
     MFTAKCAMQN IRNVAIVGSG QMGSGIAQVT ASSGFNVMLA DVNKKALDRA MKAISQSVTH
     LSKKQKGTDK EKSDFVTLTM SRIKTCNNVS TAVADADLII EAAIENIDLK RGIFAQIEQS
     CKKDSILTTN TSSFLLEDVA KGLQDKTRFG GLHFFNPVPV MKLLEVIRSD DTSDETYATL
     IKFGTAVGKT TVACKDSPGF IVNRLLIPYF FEAARMYERG DASMTDIDEA MKLGAGHPMG
     PFELADYIGL DTVKFVMDGW AAKYPEVQLF EASPLVDKLV AEGKLGRKTG DGFYSYKK
 
 
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