ID   HCDH2_CAEEL             Reviewed;         309 AA.
AC   P41938;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3;
DE            EC=1.1.1.35;
GN   ORFNames=B0272.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; Z46240; CAA86312.1; -; Genomic_DNA.
DR   PIR; T18685; T18685.
DR   RefSeq; NP_509584.1; NM_077183.5.
DR   AlphaFoldDB; P41938; -.
DR   SMR; P41938; -.
DR   BioGRID; 46085; 2.
DR   STRING; 6239.B0272.3; -.
DR   iPTMnet; P41938; -.
DR   World-2DPAGE; 0020:P41938; -.
DR   EPD; P41938; -.
DR   PaxDb; P41938; -.
DR   PeptideAtlas; P41938; -.
DR   EnsemblMetazoa; B0272.3.1; B0272.3.1; WBGene00007129.
DR   GeneID; 181169; -.
DR   KEGG; cel:CELE_B0272.3; -.
DR   UCSC; B0272.3; c. elegans.
DR   CTD; 181169; -.
DR   WormBase; B0272.3; CE00852; WBGene00007129; -.
DR   eggNOG; KOG2304; Eukaryota.
DR   GeneTree; ENSGT00940000166803; -.
DR   HOGENOM; CLU_009834_2_0_1; -.
DR   InParanoid; P41938; -.
DR   OMA; FYDYSES; -.
DR   OrthoDB; 938257at2759; -.
DR   PhylomeDB; P41938; -.
DR   Reactome; R-CEL-77310; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
DR   Reactome; R-CEL-77346; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
DR   Reactome; R-CEL-77348; Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
DR   Reactome; R-CEL-77350; Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
DR   Reactome; R-CEL-77352; Beta oxidation of butanoyl-CoA to acetyl-CoA.
DR   UniPathway; UPA00659; -.
DR   PRO; PR:P41938; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00007129; Expressed in larva and 4 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Mitochondrion; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..309
FT                   /note="Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3"
FT                   /id="PRO_0000109254"
FT   SITE            165
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   309 AA;  33380 MW;  5FC90AFA754EDD73 CRC64;
     MLSSTCTAAV RGLSTTAQLS KINNVTIIGA GLMGSGIAQV SANAKLNVTV VDSNQSALEK
     AQQGIANSLK RVAKKKHADD AAAQTALVSS VLDRIKMSTN VSDSVKDADL VIEAIVENID
     IKRKLFAEVE VAAKPTTLIT TNTSSLRLAD IGLNLKDKSR FGGLHFFNPV PMMKLLEVVR
     HTETSDATFN QLVDYGKTVG KTTVACKDTP GFIVNRLLVP YMFEALRLYE RGDASMEDID
     VAMKLGAGYP MGPFELSDYV GLDTCKFIMD GWHAQYPEEV AFTPSPLLNS LVDSGKNGRK
     SGEGFYKYK