ID   HCDH_DEIRA              Reviewed;         346 AA.
AC   P83589;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Probable 3-hydroxyacyl-CoA dehydrogenase;
DE            EC=1.1.1.35;
GN   OrderedLocusNames=DR_2477;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-16.
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RA   Joshi B.S., Apte S.K., Schmid R., Altendorf K.;
RL   Submitted (MAY-2003) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000250|UniProtKB:Q8W1L6};
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC       6.00, its MW is: 83 kDa.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000255}.
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DR   EMBL; AE000513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P83589; -.
DR   SMR; P83589; -.
DR   InParanoid; P83589; -.
DR   OrthoDB; 82358at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Fatty acid metabolism; Lipid metabolism; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Probable 3-hydroxyacyl-CoA dehydrogenase"
FT                   /id="PRO_0000308488"
FT   REGION          322..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  37540 MW;  16A529B759DBD82C CRC64;
     MKIKKAAVIG AGVMGAAIAA QLANAGIPVL LLDIVLPDKP DRNFLAKAGV ERALKARPAA
     FMDNDRARLI EVGNLEDDLK KLKDVDWVLE AIIEKLDAKH DLWEKVEKVV KKTAIISSNS
     SGIPMHLQIE GRSEDFQRRF VGAHFFNPPR YLHLLEVIPT DKTDPQVVKD FSEFAEHTLG
     KGVVVANDVP GFVANRIGVY GIVRAMQHME KYGLTPAEVD QLTGPALGRA SSATFRTADL
     SGLDIISHVA TDIGGVTPDD EDFTLTESFK NMVAGGILGD KSGSGFYKKT KDEKARPRFS
     TTCKPANTKT RARCACPPWT PRANLSPSAT PCTPWKARKA TSCAPP