ID   HCFC2_RAT               Reviewed;         723 AA.
AC   Q5RKG2;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Host cell factor 2;
DE            Short=HCF-2;
DE   AltName: Full=C2 factor;
GN   Name=Hcfc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least
CC       composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and
CC       HCFC2 (By similarity). Interacts with TASOR (By similarity).
CC       {ECO:0000250|UniProtKB:Q9D968, ECO:0000250|UniProtKB:Q9Y5Z7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5Z7}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9Y5Z7}.
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DR   EMBL; BC085951; AAH85951.1; -; mRNA.
DR   RefSeq; NP_001008358.1; NM_001008357.1.
DR   AlphaFoldDB; Q5RKG2; -.
DR   SMR; Q5RKG2; -.
DR   STRING; 10116.ENSRNOP00000014951; -.
DR   PhosphoSitePlus; Q5RKG2; -.
DR   PaxDb; Q5RKG2; -.
DR   PRIDE; Q5RKG2; -.
DR   Ensembl; ENSRNOT00000086905; ENSRNOP00000070255; ENSRNOG00000053510.
DR   GeneID; 314704; -.
DR   KEGG; rno:314704; -.
DR   UCSC; RGD:1307385; rat.
DR   CTD; 29915; -.
DR   RGD; 1307385; Hcfc2.
DR   eggNOG; KOG4152; Eukaryota.
DR   GeneTree; ENSGT00940000160733; -.
DR   InParanoid; Q5RKG2; -.
DR   OrthoDB; 416932at2759; -.
DR   PRO; PR:Q5RKG2; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0035097; C:histone methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0071339; C:MLL1 complex; ISO:RGD.
DR   GO; GO:0044665; C:MLL1/2 complex; ISO:RGD.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; ISO:RGD.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR043536; HCF1/2.
DR   InterPro; IPR037932; HCF2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46003; PTHR46003; 2.
DR   PANTHER; PTHR46003:SF2; PTHR46003:SF2; 2.
DR   Pfam; PF01344; Kelch_1; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kelch repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..723
FT                   /note="Host cell factor 2"
FT                   /id="PRO_0000119074"
FT   REPEAT          34..79
FT                   /note="Kelch 1"
FT   REPEAT          83..130
FT                   /note="Kelch 2"
FT   REPEAT          207..255
FT                   /note="Kelch 3"
FT   REPEAT          257..305
FT                   /note="Kelch 4"
FT   DOMAIN          357..436
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          516..606
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          608..720
FT                   /note="Fibronectin type-III 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          398..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  79149 MW;  FC09D7455BEEAD1F CRC64;
     MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTVTNQWF
     LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPQPPPS
     GLPPCPRLGH SFSLYGNKCY LFAGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSVP
     ATKGTVPSPR ESHTAVIYCK RDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT
     VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TENSPHDCEW RCTSSFSYLN LDTAEWTTLV
     SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
     SQVQLIKATT NSFHVKWDEV PTVEGYLLQL NTDLTHQAAS PDASAAPNTL GGRTDPHRQG
     SNSILHNSVS DPANCTKPEH TAVAARGMSL KSKPDSRAAD SSVALHSPLA PNTSNNNSCM
     ADMLWKSEVD EICALPATKI SRVEAHAAAT PFSKETPSNP VAILKAEQWC DVGIFKNNTA
     LVSQFYLLPK GKQSMSKVGN ADVPDYSLLK KQDLVPGTVY KFRVAAINGC GIGPFSKLSE
     FKTCIPGFPG APSTVRISKN VEGIHLSWEP PTSPSGNILE YSAYLAIRTA QVQDNPSQLV
     FMRIYCGLKT SCIVTAGQLA NAHIDYTSRP AIVFRISAKN EKGYGPATQV RWLQGNSKKA
     PLS