HCP5_HUMAN
ID HCP5_HUMAN Reviewed; 132 AA.
AC Q6MZN7; Q04490;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=HLA class I histocompatibility antigen protein P5;
DE AltName: Full=HLA complex protein P5;
DE AltName: Full=Protein P5-1;
GN Name=HCP5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Spleen;
RX PubMed=8462994; DOI=10.1007/bf00216390;
RA Vernet C., Ribouchon M.-T., Chimini G., Jouanolle A.-M., Sidibe I.,
RA Pontarotti P.;
RT "A novel coding sequence belonging to a new multicopy gene family mapping
RT within the human MHC class I region.";
RL Immunogenetics 38:47-53(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION.
RX PubMed=10199916; DOI=10.1007/s002510050513;
RA Kulski J.K., Dawkins R.L.;
RT "The P5 multicopy gene family in the MHC is related in sequence to human
RT endogenous retroviruses HERV-L and HERV-16.";
RL Immunogenetics 49:404-412(1999).
RN [7]
RP VARIANT GLY-112.
RX PubMed=17641165; DOI=10.1126/science.1143767;
RA Fellay J., Shianna K.V., Ge D., Colombo S., Ledergerber B., Weale M.,
RA Zhang K., Gumbs C., Castagna A., Cossarizza A., Cozzi-Lepri A., De Luca A.,
RA Easterbrook P., Francioli P., Mallal S., Martinez-Picado J., Miro J.M.,
RA Obel N., Smith J.P., Wyniger J., Descombes P., Antonarakis S.E.,
RA Letvin N.L., McMichael A.J., Haynes B.F., Telenti A., Goldstein D.B.;
RT "A whole-genome association study of major determinants for host control of
RT HIV-1.";
RL Science 317:944-947(2007).
RN [8]
RP VARIANT GLY-112.
RX PubMed=18301071; DOI=10.1097/qad.0b013e3282f470e4;
RA Han Y., Lai J., Barditch-Crovo P., Gallant J.E., Williams T.M.,
RA Siliciano R.F., Blankson J.N.;
RT "The role of protective HCP5 and HLA-C associated polymorphisms in the
RT control of HIV-1 replication in a subset of elite suppressors.";
RL AIDS 22:541-544(2008).
CC -!- TISSUE SPECIFICITY: Expressed in lymphoid tissues; Detected in spleen
CC as well as in B-cell lines, NK cell lines and activated lymphocytes.
CC {ECO:0000269|PubMed:8462994}.
CC -!- MISCELLANEOUS: Variation Gly-112 is associated with low viral loads in
CC untreated HIV patients. The level of circulating virus in the plasma of
CC HIV patients (viral set point) varies among individuals during the
CC nonsymptomatic phase preceding the progression to AIDS. This
CC polymorphism explains 9.6% of the total variation in set point and is
CC associated with the HLA-B*5701 allele, which has the strongest
CC described protective impact on HIV disease progression. However, it is
CC possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a
CC direct role in the control in viremia in HIV patients.
CC -!- MISCELLANEOUS: HCP5 is localized within the MHC class I region, but is
CC not structurally related to MHC class I genes. HCP5 is related in
CC sequence to human endogenous retroviruses HERV-L and HERV-16. It has
CC sequence homology with retroviral Pol genes in HERV retroviral element;
CC thus, it is itself a good candidate to interact with HIV-1, possibly
CC through an antisense mechanism against retroviral transcript.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA59986.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; L06175; AAA59986.1; ALT_FRAME; mRNA.
DR EMBL; AK290875; BAF83564.1; -; mRNA.
DR EMBL; BX640979; CAE45991.1; -; mRNA.
DR EMBL; CH471081; EAX03398.1; -; Genomic_DNA.
DR EMBL; BC106759; AAI06760.1; -; mRNA.
DR AlphaFoldDB; Q6MZN7; -.
DR IntAct; Q6MZN7; 1.
DR MINT; Q6MZN7; -.
DR iPTMnet; Q6MZN7; -.
DR PhosphoSitePlus; Q6MZN7; -.
DR BioMuta; HGNC:21659; -.
DR PeptideAtlas; Q6MZN7; -.
DR PRIDE; Q6MZN7; -.
DR ProteomicsDB; 66575; -.
DR GeneCards; HCP5; -.
DR HGNC; HGNC:21659; HCP5.
DR MIM; 604676; gene.
DR neXtProt; NX_Q6MZN7; -.
DR PharmGKB; PA134951826; -.
DR PathwayCommons; Q6MZN7; -.
DR ChiTaRS; HCP5; human.
DR Pharos; Q6MZN7; Tdark.
DR PRO; PR:Q6MZN7; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6MZN7; protein.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..132
FT /note="HLA class I histocompatibility antigen protein P5"
FT /id="PRO_0000329059"
FT VARIANT 32
FT /note="W -> R (in dbSNP:rs17206855)"
FT /id="VAR_042638"
FT VARIANT 82
FT /note="W -> C (in dbSNP:rs2255221)"
FT /id="VAR_042639"
FT VARIANT 93
FT /note="G -> E (in dbSNP:rs2255223)"
FT /id="VAR_042640"
FT VARIANT 112
FT /note="V -> G (associated with low viral load in HIV
FT patients; dbSNP:rs2395029)"
FT /evidence="ECO:0000269|PubMed:17641165,
FT ECO:0000269|PubMed:18301071"
FT /id="VAR_042641"
FT VARIANT 123
FT /note="H -> R (in dbSNP:rs3130907)"
FT /id="VAR_042642"
FT CONFLICT 59..60
FT /note="QG -> K (in Ref. 1; AAA59986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 14098 MW; 33BFBD82E613F773 CRC64;
MLLRMSEHRN EALGNYLEMR LKSSFLRGLG SWKSNPLRLG GWTILLTLTM GQGEPGGPQG
DPWVPHELLL PSLCDSSHAS SWGSGSITCA WRGGDSSSHP LVSGHILSNS PVAAVMCSSM
GTHLSPFKGT LL
