ID   ANF1_CHICK              Reviewed;         196 AA.
AC   P79775;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Homeobox protein ANF-1;
DE   AltName: Full=GANF;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kazanskaya O.V., Severtzova E.A., Barth K.A., Ermakova G.V., Lukyanov S.A.,
RA   Benyumov A.O., Pannese M., Boncinelli E., Wilson S.W., Zaraisky A.G.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE OF 8-196.
RC   TISSUE=Forebrain;
RX   PubMed=9373136; DOI=10.1016/s0378-1119(97)00326-0;
RA   Kazanskaya O.V., Severtzova E.A., Barth K.A., Ermakova G.V., Lukyanov S.A.,
RA   Benyumov A.O., Pannese M., Boncinelli E., Wilson S.W., Zaraisky A.G.;
RT   "Anf: a novel class of vertebrate homeobox genes expressed at the anterior
RT   end of the main embryonic axis.";
RL   Gene 200:25-34(1997).
CC   -!- FUNCTION: May be involved in the early patterning of the most anterior
CC       region of the main embryonic body axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed within the most anterior region of the
CC       embryonic body axis during gastrulation and neurulation.
CC   -!- SIMILARITY: Belongs to the ANF homeobox family. {ECO:0000305}.
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DR   EMBL; U65436; AAC24899.1; -; mRNA.
DR   AlphaFoldDB; P79775; -.
DR   SMR; P79775; -.
DR   STRING; 9031.ENSGALP00000008823; -.
DR   VEuPathDB; HostDB:geneid_395864; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   PhylomeDB; P79775; -.
DR   PRO; PR:P79775; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR043402; Hesx1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR46966; PTHR46966; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..196
FT                   /note="Homeobox protein ANF-1"
FT                   /id="PRO_0000048925"
FT   DNA_BIND        119..178
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   196 AA;  22801 MW;  1584272DE04AEF9F CRC64;
     MASTSLCAAN PSASQNLRKV SGFVENKTTQ CSFSIESILG LEQKKDGAAV KPHRPWMDGC
     MHQLGDPHLQ IPVVSYENSL FHANSNLMQE EKVLNCEKYF SVTVTERLSF KRELSWYRGR
     RPRTAFTRNQ IEVLENVFKM NSYPGIDIRE ELARKLDLEE DRIQIWFQNR RAKLKRSHRE
     SQFLMVKNNF TSSLLE