ID   ANFB_ACITR              Reviewed;         150 AA.
AC   P83965;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Brain natriuretic peptide;
DE   AltName: Full=B-type natriuretic peptide;
DE   Flags: Precursor;
GN   Name=nppb; Synonyms=bnp;
OS   Acipenser transmontanus (White sturgeon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX   NCBI_TaxID=7904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Heart ventricle;
RX   PubMed=15072558; DOI=10.1677/jme.0.0320547;
RA   Kawakoshi A., Hyodo S., Inoue K., Kobayashi Y., Takei Y.;
RT   "Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon:
RT   identification of BNP in fish lineage.";
RL   J. Mol. Endocrinol. 32:547-555(2004).
CC   -!- FUNCTION: Cardiac hormone which may function as a paracrine
CC       antifibrotic factor in the heart. Also plays a key role in
CC       cardiovascular homeostasis through natriuresis, diuresis,
CC       vasorelaxation, and inhibition of renin and aldosterone secretion (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Atrium and ventricle, and to a lessex extent in
CC       brain. {ECO:0000269|PubMed:15072558}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB087729; BAD02836.1; -; mRNA.
DR   AlphaFoldDB; P83965; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002407; Natriuretic_peptide_atrial.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00711; ANATPEPTIDE.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..?
FT                   /id="PRO_0000001543"
FT   PEPTIDE         ?..150
FT                   /note="Brain natriuretic peptide"
FT                   /id="PRO_0000001544"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        123..139
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   150 AA;  16758 MW;  AD5AA59C0BC292AB CRC64;
     MLGSRLTFCY GFLHLLLQTH VLVCAYPNSD AVVRDTDTLK TLLQRLEEAY LLTVRAESLE
     RGQVADGMPE EQSYEAEDGS QERLAEESAI GYITLDAEEA RLPDRNSNGF LNPLRNTKRY
     SGCFGRRLDR IGSMSALGCN GGSRLSYKRS