ID   ANFB_OREMO              Reviewed;         138 AA.
AC   Q805E8;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Brain natriuretic peptide;
DE   AltName: Full=B-type natriuretic peptide;
DE   Flags: Precursor;
GN   Name=nppb; Synonyms=bnp;
OS   Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=15072558; DOI=10.1677/jme.0.0320547;
RA   Kawakoshi A., Hyodo S., Inoue K., Kobayashi Y., Takei Y.;
RT   "Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon:
RT   identification of BNP in fish lineage.";
RL   J. Mol. Endocrinol. 32:547-555(2004).
CC   -!- FUNCTION: Cardiac hormone which may function as a paracrine
CC       antifibrotic factor in the heart. Also plays a key role in
CC       cardiovascular homeostasis through natriuresis, diuresis,
CC       vasorelaxation, and inhibition of renin and aldosterone secretion (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB087284; BAC55025.1; -; mRNA.
DR   AlphaFoldDB; Q805E8; -.
DR   SMR; Q805E8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..?
FT                   /id="PRO_0000001547"
FT   PEPTIDE         ?..138
FT                   /note="Brain natriuretic peptide"
FT                   /id="PRO_0000001548"
FT   REGION          50..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        111..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   138 AA;  15189 MW;  5A023AB1F4F452FA CRC64;
     MRLSSMWLCS LLLILKLQLS STYPISTGLT DTDMDILKVL LSRLEESVSE QMAVDQSAPG
     QRDLLDSLST EDAGDGPQPD AGLDEAEIRE FLSAKNLKSV RNDSSRRSSG CFGRRMDRIG
     SMSSLGCNTV GRYNPKQR