ID   ANFB_TAKRU              Reviewed;         133 AA.
AC   Q805D7;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Brain natriuretic peptide;
DE   AltName: Full=B-type natriuretic peptide;
DE   Flags: Precursor;
GN   Name=nppb; Synonyms=bnp;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=15072558; DOI=10.1677/jme.0.0320547;
RA   Kawakoshi A., Hyodo S., Inoue K., Kobayashi Y., Takei Y.;
RT   "Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon:
RT   identification of BNP in fish lineage.";
RL   J. Mol. Endocrinol. 32:547-555(2004).
CC   -!- FUNCTION: Cardiac hormone which may function as a paracrine
CC       antifibrotic factor in the heart. Also plays a key role in
CC       cardiovascular homeostasis through natriuresis, diuresis,
CC       vasorelaxation, and inhibition of renin and aldosterone secretion. Has
CC       a cGMP-stimulating activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB089934; BAC57070.1; -; mRNA.
DR   RefSeq; NP_001027860.1; NM_001032688.1.
DR   AlphaFoldDB; Q805D7; -.
DR   STRING; 31033.ENSTRUP00000002258; -.
DR   GeneID; 446068; -.
DR   KEGG; tru:446068; -.
DR   CTD; 4879; -.
DR   HOGENOM; CLU_126636_0_0_1; -.
DR   InParanoid; Q805D7; -.
DR   OrthoDB; 1493586at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..?
FT                   /id="PRO_0000001545"
FT   PEPTIDE         ?..133
FT                   /note="Brain natriuretic peptide"
FT                   /id="PRO_0000001546"
FT   REGION          44..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        108..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   133 AA;  14746 MW;  FD4541B255A33436 CRC64;
     MVVSFVSICG LLLIFNLPLS TSFPVLSDTD VDVLEAILHK LEESMSEETE EDQMVPANSE
     SLEPVGSMKQ TANRDQIRPV EVEAIREFLS ANTRKNVQND SSRRSSSCFG RRMDRIGSMS
     SLGCNTVGKY NPK