ID   ANFC1_ONCMY             Reviewed;         131 AA.
AC   Q8AXR3;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=C-type natriuretic peptide 1;
DE   AltName: Full=C-type natriuretic peptide I;
DE   AltName: Full=CNP-22 I;
DE   Flags: Precursor;
GN   Name=cnp-1 {ECO:0000312|EMBL:BAC44842.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAC44842.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND SYNTHESIS.
RC   TISSUE=Brain {ECO:0000269|PubMed:12568796};
RX   PubMed=12568796; DOI=10.1016/s0016-6480(02)00591-9;
RA   Inoue K., Russell M.J., Olson K.R., Takei Y.;
RT   "C-type natriuretic peptide of rainbow trout (Oncorhynchus mykiss): primary
RT   structure and vasorelaxant activities.";
RL   Gen. Comp. Endocrinol. 130:185-192(2003).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressant activity. Has a cGMP-
CC       stimulating activity. {ECO:0000250|UniProtKB:P18145,
CC       ECO:0000269|PubMed:12568796}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in brain and to a low extent in atrium.
CC       {ECO:0000269|PubMed:12568796}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC       {ECO:0000255|RuleBase:RU003686}.
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DR   EMBL; AB076601; BAC44842.1; -; mRNA.
DR   RefSeq; NP_001123455.1; NM_001129983.1.
DR   AlphaFoldDB; Q8AXR3; -.
DR   Ensembl; ENSOMYT00000068038; ENSOMYP00000062476; ENSOMYG00000028902.
DR   GeneID; 100170203; -.
DR   GeneTree; ENSGT00390000015492; -.
DR   OrthoDB; 1491136at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IDA:AgBase.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal; Vasoactive.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..109
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001589"
FT   PEPTIDE         110..131
FT                   /note="C-type natriuretic peptide 1"
FT                   /id="PRO_0000001590"
FT   DISULFID        115..131
FT                   /evidence="ECO:0000250|UniProtKB:P18145"
SQ   SEQUENCE   131 AA;  14462 MW;  3A98A2CB78A4F1C3 CRC64;
     MLYPALLCAA LLLIAPLGHT EGRTLHPSPD AIQFVEQFLD RYNDLTLDDL ENLVSSQPEE
     PSSAFTSGVK VAEYPKWADI PAQGDSTWLR LLKGTLANQK RAVMDRSRRG WNRGCFGLKL
     DRIGSMSGLG C