位置:首页 > 蛋白库 > ANFC2_TAKRU
ANFC2_TAKRU
ID   ANFC2_TAKRU             Reviewed;         130 AA.
AC   Q805D5;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=C-type natriuretic peptide 2;
DE   Flags: Precursor;
GN   Name=cnp-2 {ECO:0000312|EMBL:BAC57072.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1] {ECO:0000312|EMBL:BAC57072.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:BAC57072.1};
RX   PubMed=12893874; DOI=10.1073/pnas.1632368100;
RA   Inoue K., Naruse K., Yamagami S., Mitani H., Suzuki N., Takei Y.;
RT   "Four functionally distinct C-type natriuretic peptides found in fish
RT   reveal evolutionary history of the natriuretic peptide system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10079-10084(2003).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressant activity. Has cGMP-
CC       stimulating activity. May help to regulate body fluid homeostasis in a
CC       variety of aquatic environments. {ECO:0000250|UniProtKB:P18145,
CC       ECO:0000303|PubMed:12893874}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC       {ECO:0000255|RuleBase:RU003686}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB089936; BAC57072.1; -; mRNA.
DR   RefSeq; NP_001027907.1; NM_001032735.1.
DR   AlphaFoldDB; Q805D5; -.
DR   STRING; 31033.ENSTRUP00000002144; -.
DR   Ensembl; ENSTRUT00000079623; ENSTRUP00000058470; ENSTRUG00000033063.
DR   GeneID; 445905; -.
DR   KEGG; tru:445905; -.
DR   eggNOG; KOG3368; Eukaryota.
DR   GeneTree; ENSGT00500000046195; -.
DR   HOGENOM; CLU_983390_0_0_1; -.
DR   InParanoid; Q805D5; -.
DR   OrthoDB; 1491136at2759; -.
DR   Proteomes; UP000005226; Chromosome 8.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..103
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001583"
FT   PEPTIDE         104..130
FT                   /note="C-type natriuretic peptide 2"
FT                   /id="PRO_0000001584"
FT   REGION          57..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        114..130
FT                   /evidence="ECO:0000250|UniProtKB:P18145"
SQ   SEQUENCE   130 AA;  13792 MW;  41BE1FCC1A5F7E4C CRC64;
     MAASSSSFVP LVLLFLAIPV EPRPSMTRDE AQVLRALFGA RLSSIISTPV NTDDIAELLP
     RRPGPPRSFG ASPGALRGLT RGSEGGSRFL LDFLQQQSKT TRRGRSSMVG GRGCFGMKID
     RIGSISGLGC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024