ID   HD12_ENCCU              Reviewed;         193 AA.
AC   Q8SRR1; Q7SI82;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox protein HD-12;
DE   AltName: Full=EcHD-12;
GN   Name=HD-12; OrderedLocusNames=ECU06_0740;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family. {ECO:0000305}.
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DR   EMBL; AL590446; CAD25434.1; -; Genomic_DNA.
DR   EMBL; BK001347; DAA01310.1; -; Genomic_DNA.
DR   RefSeq; NP_585830.1; NM_001041452.1.
DR   AlphaFoldDB; Q8SRR1; -.
DR   SMR; Q8SRR1; -.
DR   STRING; 284813.Q8SRR1; -.
DR   GeneID; 859254; -.
DR   KEGG; ecu:ECU06_0740; -.
DR   VEuPathDB; MicrosporidiaDB:ECU06_0740; -.
DR   HOGENOM; CLU_106819_0_0_1; -.
DR   InParanoid; Q8SRR1; -.
DR   OMA; PEIDDEC; -.
DR   OrthoDB; 1569580at2759; -.
DR   Proteomes; UP000000819; Chromosome VI.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..193
FT                   /note="Homeobox protein HD-12"
FT                   /id="PRO_0000048921"
FT   DNA_BIND        123..185
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   193 AA;  22973 MW;  9DCEB92E087F322F CRC64;
     MMRHINEILI AKEKYFQSSI NDHDLKEIIL KIQQDCITYH STDLLGSSLL HKLILILIIE
     KFKSLLLFEK NIISIFDLEC VNFQEEMNSI MYVMNEVEKQ YLRSDKFSTH NHSLTGGLFA
     SNSVIRRINF PKEISKILRK WLKKHLTYPY PSKIEKKMLS KETGLKLSQI DNWFANARRR
     ILPFMKEKFI DFD