ID   HD1_ENCCU               Reviewed;         151 AA.
AC   Q8SUB7; Q7SI93;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Homeobox protein HD-1;
DE   AltName: Full=EcHD-1;
GN   Name=HD-1; OrderedLocusNames=ECU10_1470;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GB-M1;
RX   PubMed=20003517; DOI=10.1186/1471-2164-10-607;
RA   Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P.,
RA   Cornman R.S., Evans J.D., Delbac F., Peyret P.;
RT   "Identification of transcriptional signals in Encephalitozoon cuniculi
RT   widespread among Microsporidia phylum: support for accurate structural
RT   genome annotation.";
RL   BMC Genomics 10:607-607(2009).
RN   [3]
RP   GENE NAME.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA01299.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL590449; CAD25866.2; -; Genomic_DNA.
DR   EMBL; BK001336; DAA01299.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_586262.1; NM_001042095.1.
DR   AlphaFoldDB; Q8SUB7; -.
DR   SMR; Q8SUB7; -.
DR   STRING; 284813.Q8SUB7; -.
DR   GeneID; 859912; -.
DR   KEGG; ecu:ECU10_1470; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_1470; -.
DR   HOGENOM; CLU_145531_0_0_1; -.
DR   InParanoid; Q8SUB7; -.
DR   OrthoDB; 1442986at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..151
FT                   /note="Homeobox protein HD-1"
FT                   /id="PRO_0000048910"
FT   DNA_BIND        87..146
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   151 AA;  17671 MW;  FE83E1E8E5A352E2 CRC64;
     MSKLPALVSL RMNEIRGIYI ETNNRVVEEM DAVIDEFAKD VGSSPDISTN VRTYLEERIR
     YIREFVVDHI GFSISEFRTL YNPNGNESIK SRRFPKFITE ALERSFEIDQ YPSEAEKARL
     AKICKLSTKQ INNWFTNKRN RTKGHEGGRQ Y