ID   HD2_ENCCU               Reviewed;         192 AA.
AC   Q8SR09; Q7SI92;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox protein HD-2;
DE   AltName: Full=EcHD-2;
GN   Name=HD-2; OrderedLocusNames=ECU10_1480;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family. {ECO:0000305}.
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DR   EMBL; AL590449; CAD25867.1; -; Genomic_DNA.
DR   EMBL; BK001337; DAA01300.1; -; Genomic_DNA.
DR   RefSeq; NP_586263.1; NM_001042096.1.
DR   AlphaFoldDB; Q8SR09; -.
DR   SMR; Q8SR09; -.
DR   STRING; 284813.Q8SR09; -.
DR   GeneID; 859914; -.
DR   KEGG; ecu:ECU10_1480; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_1480; -.
DR   HOGENOM; CLU_106819_0_0_1; -.
DR   InParanoid; Q8SR09; -.
DR   OMA; CEIIMET; -.
DR   OrthoDB; 1240969at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..192
FT                   /note="Homeobox protein HD-2"
FT                   /id="PRO_0000048911"
FT   DNA_BIND        122..184
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   192 AA;  21870 MW;  DAE11B060EE0CF9C CRC64;
     MEAMNIIMGI LDQAVSAEEG YFAGGASRKS LMEEMRRIRS KYKATVFGDS GREGMKFKMA
     LLFVLKRVKQ KIILEDRLME VIDSEVAYII GCVKSITSEP IRVGTVEAVR PIQHEAEHKC
     AKPRTRANFP MDTSQLLRSW LKENMDNPYP SDAEKAYLCQ KTGLGPAQIN NWFINARRRI
     LPFMKGKCSN FK