ID   HD3_ENCCU               Reviewed;         107 AA.
AC   Q8SVD3; Q7SI83;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Homeobox protein HD-3;
DE   AltName: Full=EcHD-3;
GN   Name=HD-3; OrderedLocusNames=ECU06_0500;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590446; CAD25410.1; -; Genomic_DNA.
DR   EMBL; BK001346; DAA01309.1; -; Genomic_DNA.
DR   RefSeq; NP_585806.1; NM_001041428.1.
DR   AlphaFoldDB; Q8SVD3; -.
DR   SMR; Q8SVD3; -.
DR   GeneID; 859230; -.
DR   KEGG; ecu:ECU06_0500; -.
DR   VEuPathDB; MicrosporidiaDB:ECU06_0500; -.
DR   HOGENOM; CLU_173461_0_0_1; -.
DR   InParanoid; Q8SVD3; -.
DR   OrthoDB; 1620366at2759; -.
DR   Proteomes; UP000000819; Chromosome VI.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..107
FT                   /note="Homeobox protein HD-3"
FT                   /id="PRO_0000048912"
FT   DNA_BIND        6..65
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   107 AA;  11927 MW;  0DC908F8D776F48A CRC64;
     MSRKESKAPR TRMTAGQTRV LMSFFKDNPF PSTTAREKLS KVLGVGPRTV QIWFQNQRQK
     ARGQAKVSDR EEGPRACTGS ECLGKLCILA CAAISRMEEE AAWNLGH