ID   HD4_ENCCU               Reviewed;         132 AA.
AC   Q8STR8; Q7SI86;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Homeobox protein HD-4;
DE   AltName: Full=EcHD-4;
GN   Name=HD-4; OrderedLocusNames=ECU09_0970;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; AL590451; CAD27070.1; -; Genomic_DNA.
DR   EMBL; BK001343; DAA01306.1; -; Genomic_DNA.
DR   RefSeq; XP_955651.1; XM_950558.1.
DR   AlphaFoldDB; Q8STR8; -.
DR   SMR; Q8STR8; -.
DR   GeneID; 860436; -.
DR   KEGG; ecu:ECU09_0970; -.
DR   VEuPathDB; MicrosporidiaDB:ECU09_0970; -.
DR   HOGENOM; CLU_128308_1_0_1; -.
DR   InParanoid; Q8STR8; -.
DR   OrthoDB; 1529443at2759; -.
DR   Proteomes; UP000000819; Chromosome IX.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..132
FT                   /note="Homeobox protein HD-4"
FT                   /id="PRO_0000048913"
FT   DNA_BIND        29..88
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          82..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   132 AA;  15134 MW;  99404E2CC08589B7 CRC64;
     MKDPRWIMEG EAMAGLVKLR RLSDKSYLGL SGYRYKTHIQ VYVLTKIFEI TQYPSHDTRQ
     NLAILLNMSP RTIQIWFQNS RSVSRGAAKK KVSKDNGPQE APKAKIVSNL TVPVKYITWL
     ILSYPSYSQI GN