ID   HD5_ENCCU               Reviewed;         133 AA.
AC   Q8SVT3; Q7SI84;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Homeobox protein HD-5;
DE   AltName: Full=EcHD-5;
GN   Name=HD-5; OrderedLocusNames=ECU04_1030;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; AL590444; CAD25291.1; -; Genomic_DNA.
DR   EMBL; BK001345; DAA01308.1; -; Genomic_DNA.
DR   RefSeq; NP_584787.1; NM_001041137.1.
DR   AlphaFoldDB; Q8SVT3; -.
DR   SMR; Q8SVT3; -.
DR   STRING; 284813.Q8SVT3; -.
DR   GeneID; 858935; -.
DR   KEGG; ecu:ECU04_1030; -.
DR   VEuPathDB; MicrosporidiaDB:ECU04_1030; -.
DR   HOGENOM; CLU_1928233_0_0_1; -.
DR   InParanoid; Q8SVT3; -.
DR   OrthoDB; 1486405at2759; -.
DR   Proteomes; UP000000819; Chromosome IV.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..133
FT                   /note="Homeobox protein HD-5"
FT                   /id="PRO_0000048914"
FT   DNA_BIND        34..93
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          86..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  15457 MW;  7382B96FC7C5D9AB CRC64;
     MSIRSKFNKD EKKFVKFIDS TEEIIKHLNK SDSSKRSRLK LSGQQIDVLE SNFKIDSHPN
     SATKSLLSNA LSIPLKNIQI WFQNRRAKEK TARDGGRRRS GNAEIEDGEY EHGKMSYQAM
     CPFDFPPQER YFL