ID   ANFC_BOVIN              Reviewed;         126 AA.
AC   P55206; A4FUX3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=C-type natriuretic peptide;
DE   AltName: Full=SVSP15;
DE   Contains:
DE     RecName: Full=CNP-22;
DE   Contains:
DE     RecName: Full=CNP-29;
DE   Contains:
DE     RecName: Full=CNP-53;
DE   Flags: Precursor;
GN   Name=NPPC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8011167; DOI=10.1089/dna.1994.13.409;
RA   Hosang K.K., Scheit K.K.;
RT   "cDNA cloning identified a calmodulin-binding protein in bovine seminal
RT   plasma as bovine C-type natriuretic peptide.";
RL   DNA Cell Biol. 13:409-417(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: [CNP-22]: Hormone which plays a role in endochondral
CC       ossification through regulation of cartilaginous growth plate
CC       chondrocytes proliferation and differentiation (By similarity). May
CC       also be vasoactive and natriuretic. Acts by specifically binding and
CC       stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By
CC       similarity). {ECO:0000250|UniProtKB:P23582,
CC       ECO:0000250|UniProtKB:Q61839}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: [CNP-22]: Degraded by IDE (in vitro).
CC       {ECO:0000250|UniProtKB:P23582}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; Z48478; CAA88369.1; -; mRNA.
DR   EMBL; Z48477; CAA88368.1; -; mRNA.
DR   EMBL; BC123399; AAI23400.1; -; mRNA.
DR   RefSeq; NP_776550.1; NM_174125.2.
DR   RefSeq; XP_005202943.1; XM_005202886.3.
DR   AlphaFoldDB; P55206; -.
DR   STRING; 9913.ENSBTAP00000040960; -.
DR   PaxDb; P55206; -.
DR   Ensembl; ENSBTAT00000063429; ENSBTAP00000055472; ENSBTAG00000003253.
DR   GeneID; 281356; -.
DR   KEGG; bta:281356; -.
DR   CTD; 4880; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003253; -.
DR   VGNC; VGNC:32212; NPPC.
DR   eggNOG; ENOG502S2QY; Eukaryota.
DR   GeneTree; ENSGT00390000015492; -.
DR   HOGENOM; CLU_160791_0_0_1; -.
DR   InParanoid; P55206; -.
DR   OrthoDB; 1491136at2759; -.
DR   TreeFam; TF106305; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000003253; Expressed in mammary gland fat and 82 other tissues.
DR   ExpressionAtlas; P55206; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051427; F:hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; ISS:AgBase.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; ISS:UniProtKB.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Osteogenesis;
KW   Reference proteome; Secreted; Signal; Vasoactive.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..73
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000001549"
FT   PEPTIDE         74..126
FT                   /note="CNP-53"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001550"
FT   PEPTIDE         98..126
FT                   /note="CNP-29"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001551"
FT   PEPTIDE         105..126
FT                   /note="CNP-22"
FT                   /id="PRO_0000001552"
FT   REGION          20..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        110..126
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   126 AA;  13291 MW;  31EDF80F4A98DD77 CRC64;
     MHLSQLLACA LLLALLSLRP SEAKPGAPPK VPRTPSGEEV AEPQAAGGGQ KKGDKTPGGG
     GANLKDDRSR LLRDLRVDTK SRAAWTRLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS
     MSGLGC