ID   HD8_ENCCU               Reviewed;         125 AA.
AC   Q8SW51; Q7SI90;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Homeobox protein HD-8;
DE   AltName: Full=EcHD-8;
GN   Name=HD-8; OrderedLocusNames=ECU03_0600;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=12590353; DOI=10.1007/s00427-002-0287-3;
RA   Buerglin T.R.;
RT   "The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a
RT   putative mating-type locus.";
RL   Dev. Genes Evol. 213:50-52(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; AL590443; CAD26206.1; -; Genomic_DNA.
DR   EMBL; BK001339; DAA01302.1; -; Genomic_DNA.
DR   RefSeq; NP_597571.1; NM_001040935.1.
DR   AlphaFoldDB; Q8SW51; -.
DR   SMR; Q8SW51; -.
DR   STRING; 284813.Q8SW51; -.
DR   GeneID; 858733; -.
DR   KEGG; ecu:ECU03_0600; -.
DR   VEuPathDB; MicrosporidiaDB:ECU03_0600; -.
DR   HOGENOM; CLU_128308_0_0_1; -.
DR   InParanoid; Q8SW51; -.
DR   OrthoDB; 1530285at2759; -.
DR   Proteomes; UP000000819; Chromosome III.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Homeobox protein HD-8"
FT                   /id="PRO_0000048917"
FT   DNA_BIND        30..89
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   125 AA;  14342 MW;  6CCD4F3EA61C1309 CRC64;
     MRKNDFDVRE MNAALGILKL AREGRGDSDE PDTRTRKTTF QMMVLKEVFK IAPHPSTLTK
     ADLALMIKLP LKAVQIWFQN ERSRKERGGR LGKRTRGGKS ESIDPVRLFK VIMKVLEKNR
     EGLGF