ID   ANFC_CHICK              Reviewed;          22 AA.
AC   P21805;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=C-type natriuretic peptide;
DE            Short=CNP;
GN   Name=NPPC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=1989595; DOI=10.1016/0006-291x(91)90497-u;
RA   Arimura J.J., Minamino N., Kangawa K., Matsuo H.;
RT   "Isolation and identification of C-type natriuretic peptide in chicken
RT   brain.";
RL   Biochem. Biophys. Res. Commun. 174:142-148(1991).
CC   -!- FUNCTION: Hormone which plays a role in endochondral ossification
CC       through regulation of cartilaginous growth plate chondrocytes
CC       proliferation and differentiation. May also be vasoactive and
CC       natriuretic. Specifically binds and stimulates the cGMP production of
CC       the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   PIR; JT0581; JT0581.
DR   AlphaFoldDB; P21805; -.
DR   STRING; 9031.ENSGALP00000007266; -.
DR   PaxDb; P21805; -.
DR   eggNOG; ENOG502S7N9; Eukaryota.
DR   HOGENOM; CLU_160791_0_0_1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Vasoactive.
FT   PEPTIDE         1..22
FT                   /note="C-type natriuretic peptide"
FT                   /id="PRO_0000043486"
FT   DISULFID        6..22
SQ   SEQUENCE   22 AA;  2244 MW;  FC2A4706D8DAC025 CRC64;
     GLSRSCFGVK LDRIGSMSGL GC