HDA11_MOUSE
ID HDA11_MOUSE Reviewed; 347 AA.
AC Q91WA3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Histone deacetylase 11;
DE Short=HD11;
DE EC=3.5.1.98;
GN Name=Hdac11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Responsible for the deacetylation of lysine residues on the
CC N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC deacetylation gives a tag for epigenetic repression and plays an
CC important role in transcriptional regulation, cell cycle progression
CC and developmental events. Histone deacetylases act via the formation of
CC large multiprotein complexes (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC -!- SUBUNIT: Interacts with HDAC6. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone
CC deacetylase inhibitor. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC016208; AAH16208.1; -; mRNA.
DR CCDS; CCDS20366.1; -.
DR RefSeq; NP_659168.1; NM_144919.2.
DR AlphaFoldDB; Q91WA3; -.
DR SMR; Q91WA3; -.
DR BioGRID; 231232; 4.
DR IntAct; Q91WA3; 1.
DR MINT; Q91WA3; -.
DR STRING; 10090.ENSMUSP00000043828; -.
DR BindingDB; Q91WA3; -.
DR ChEMBL; CHEMBL3832944; -.
DR iPTMnet; Q91WA3; -.
DR PhosphoSitePlus; Q91WA3; -.
DR MaxQB; Q91WA3; -.
DR PaxDb; Q91WA3; -.
DR PRIDE; Q91WA3; -.
DR ProteomicsDB; 269818; -.
DR Antibodypedia; 10901; 446 antibodies from 38 providers.
DR DNASU; 232232; -.
DR Ensembl; ENSMUST00000041736; ENSMUSP00000043828; ENSMUSG00000034245.
DR GeneID; 232232; -.
DR KEGG; mmu:232232; -.
DR UCSC; uc009cxv.1; mouse.
DR CTD; 79885; -.
DR MGI; MGI:2385252; Hdac11.
DR VEuPathDB; HostDB:ENSMUSG00000034245; -.
DR eggNOG; KOG1344; Eukaryota.
DR GeneTree; ENSGT00940000156308; -.
DR HOGENOM; CLU_007727_1_1_1; -.
DR InParanoid; Q91WA3; -.
DR OMA; RVFTFSM; -.
DR OrthoDB; 1037375at2759; -.
DR PhylomeDB; Q91WA3; -.
DR TreeFam; TF106176; -.
DR Reactome; R-MMU-350054; Notch-HLH transcription pathway.
DR BioGRID-ORCS; 232232; 3 hits in 76 CRISPR screens.
DR PRO; PR:Q91WA3; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q91WA3; protein.
DR Bgee; ENSMUSG00000034245; Expressed in dorsomedial nucleus of hypothalamus and 232 other tissues.
DR ExpressionAtlas; Q91WA3; baseline and differential.
DR Genevisible; Q91WA3; MM.
DR GO; GO:0005737; C:cytoplasm; TAS:UniProtKB.
DR GO; GO:0000118; C:histone deacetylase complex; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; TAS:UniProtKB.
DR GO; GO:0004407; F:histone deacetylase activity; ISO:MGI.
DR GO; GO:0006325; P:chromatin organization; TAS:UniProtKB.
DR GO; GO:0016575; P:histone deacetylation; ISO:MGI.
DR GO; GO:0014003; P:oligodendrocyte development; ISO:MGI.
DR CDD; cd09993; HDAC_classIV; 1.
DR Gene3D; 3.40.800.20; -; 1.
DR InterPro; IPR044150; HDAC_classIV.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; SSF52768; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Hydrolase; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..347
FT /note="Histone deacetylase 11"
FT /id="PRO_0000114717"
FT REGION 14..318
FT /note="Histone deacetylase"
FT ACT_SITE 143
FT /evidence="ECO:0000250"
SQ SEQUENCE 347 AA; 39157 MW; 7AD91D1B28D57B8E CRC64;
MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML
VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL
DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER
NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP
