ID   HDA2_ASHGO              Reviewed;         665 AA.
AC   Q75EZ7;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=HDA1 complex subunit 2;
DE   AltName: Full=Histone deacetylase complex 1 subunit 2;
GN   Name=HDA2; OrderedLocusNames=AAL069C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for activity of histone deacetylase complexes that
CC       are responsible for the deacetylation of lysine residues on the N-
CC       terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC       deacetylation gives a tag for epigenetic repression and plays an
CC       important role in transcriptional regulation, cell cycle progression
CC       and developmental events (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of some histone deacetylase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HDA2/3 family. HDA2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE016814; AAS50297.1; -; Genomic_DNA.
DR   RefSeq; NP_982473.1; NM_207826.2.
DR   AlphaFoldDB; Q75EZ7; -.
DR   SMR; Q75EZ7; -.
DR   STRING; 33169.AAS50297; -.
DR   EnsemblFungi; AAS50297; AAS50297; AGOS_AAL069C.
DR   GeneID; 4618791; -.
DR   KEGG; ago:AGOS_AAL069C; -.
DR   eggNOG; ENOG502QU6B; Eukaryota.
DR   HOGENOM; CLU_409446_0_0_1; -.
DR   InParanoid; Q75EZ7; -.
DR   OMA; DHYMPRQ; -.
DR   Proteomes; UP000000591; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0070823; C:HDA1 complex; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:EnsemblFungi.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:EnsemblFungi.
DR   GO; GO:0016575; P:histone deacetylation; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.12360; -; 1.
DR   InterPro; IPR038609; HDA1_su2/3_sf.
DR   InterPro; IPR021006; Hda2/3.
DR   Pfam; PF11496; HDA2-3; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..665
FT                   /note="HDA1 complex subunit 2"
FT                   /id="PRO_0000083929"
FT   REGION          181..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          457..625
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        183..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  75269 MW;  C634D9B08154225D CRC64;
     MNFCSKNAQM YYIPVGLTSL QKDLIEILLC MHAESFLEEF GPSEAVMQSA AQIKTEKEPE
     AVEGLGLGPL TPTQMNTMLL RHLRAVANHP CLLVDHYMPR KFLLMEPGEE LIAMSEKFRV
     LNQMMEAILS RRRRQRPLQL VLVSHSVKEL DLIEGFMLGK MVKIKRLSGT SLFDEKHQYT
     ERGTAAAESN STLTSGSTLK DTSPGSVEGK LSSGEAGAGY TTGGIKDDYD YQNSRRHMRA
     ADDGAERQCD HEDWLFLATT THLTHCTDLF DQYDVDVVLS LDPLLDVSLP ALRSVRKQSK
     SVPLVKLFVQ DSAEHFMLTR GISAEHEEDH IYDAVGHFIK NRGVHRQRLG MSAAALAEVV
     TALLENCEAA TDLKSTKPTD TPSELSIVDA LSERIMLLKL NHTPYELPLQ RGPFSMKSYQ
     LQLKQLIYAR LEACQREQEC KCAYILDRRM QETANLNRLD EVNAEAGRLF QSLKDEEKLV
     VDSERRLERT RDEHDRLREK SAHLRRRKAE LEELLASSDL DSRVSSKRAR LAELRQQLMP
     LEQQNTAMAD SNEELRTRYQ TRSSHAATLS SALASLRERK AALTKESTGP ATCWMAASAT
     EEHDRLQTEL NDLVQQRHFL QKYIDTMKSQ YAITNLDELN RTQHNKSGAA TSRVRTTRAT
     SPTYI