ANFC_MOUSE
ID ANFC_MOUSE Reviewed; 126 AA.
AC Q61839;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=C-type natriuretic peptide;
DE Contains:
DE RecName: Full=CNP-22;
DE Contains:
DE RecName: Full=CNP-29;
DE Contains:
DE RecName: Full=CNP-53;
DE Flags: Precursor;
GN Name=Nppc; Synonyms=Cnp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=7698765; DOI=10.1006/geno.1994.1633;
RA Ogawa Y., Itoh H., Yoshitake Y., Inoue M., Yoshimasa T., Serikawa T.,
RA Nakao K.;
RT "Molecular cloning and chromosomal assignment of the mouse C-type
RT natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene
RT (NPPC).";
RL Genomics 24:383-387(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=8897953; DOI=10.1152/ajpheart.1996.271.4.h1565;
RA Huang H., Acuff C.G., Steinhelper M.E.;
RT "Isolation, mapping, and regulated expression of the gene encoding mouse C-
RT type natriuretic peptide.";
RL Am. J. Physiol. 271:H1565-H1575(1996).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11259675; DOI=10.1073/pnas.071389098;
RA Chusho H., Tamura N., Ogawa Y., Yasoda A., Suda M., Miyazawa T.,
RA Nakamura K., Nakao K., Kurihara T., Komatsu Y., Itoh H., Tanaka K.,
RA Saito Y., Katsuki M., Nakao K.;
RT "Dwarfism and early death in mice lacking C-type natriuretic peptide.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4016-4021(2001).
RN [4]
RP FUNCTION.
RX PubMed=12890708; DOI=10.1038/sj.bjp.0705365;
RA Madhani M., Scotland R.S., MacAllister R.J., Hobbs A.J.;
RT "Vascular natriuretic peptide receptor-linked particulate guanylate
RT cyclases are modulated by nitric oxide-cyclic GMP signalling.";
RL Br. J. Pharmacol. 139:1289-1296(2003).
CC -!- FUNCTION: [CNP-22]: Hormone which plays a role in endochondral
CC ossification through regulation of cartilaginous growth plate
CC chondrocytes proliferation and differentiation (PubMed:11259675). May
CC also be vasoactive and natriuretic (By similarity). Acts by
CC specifically binding and stimulating NPR2 to produce cGMP
CC (PubMed:12890708). Binds the clearance receptor NPR3 (By similarity).
CC {ECO:0000250|UniProtKB:P23582, ECO:0000269|PubMed:11259675,
CC ECO:0000269|PubMed:12890708}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: [CNP-22]: Degraded by IDE (in vitro).
CC {ECO:0000250|UniProtKB:P23582}.
CC -!- DISRUPTION PHENOTYPE: Mice are viable perinatally but less than half
CC survive postnatally due to skeletal abnormalities. They display severe
CC dwarfism which is the consequence of a defect in endochondral
CC ossification. {ECO:0000269|PubMed:11259675}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR EMBL; D28873; BAA06028.1; -; Genomic_DNA.
DR EMBL; U62939; AAB61717.1; -; Genomic_DNA.
DR CCDS; CCDS15123.1; -.
DR PIR; A55688; A55688.
DR RefSeq; NP_035063.1; NM_010933.5.
DR AlphaFoldDB; Q61839; -.
DR BioGRID; 201829; 1.
DR STRING; 10090.ENSMUSP00000027449; -.
DR PhosphoSitePlus; Q61839; -.
DR SwissPalm; Q61839; -.
DR PaxDb; Q61839; -.
DR PRIDE; Q61839; -.
DR ProteomicsDB; 296289; -.
DR Antibodypedia; 50954; 291 antibodies from 31 providers.
DR DNASU; 18159; -.
DR Ensembl; ENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
DR GeneID; 18159; -.
DR KEGG; mmu:18159; -.
DR UCSC; uc007bvt.2; mouse.
DR CTD; 4880; -.
DR MGI; MGI:97369; Nppc.
DR VEuPathDB; HostDB:ENSMUSG00000026241; -.
DR eggNOG; ENOG502S2QY; Eukaryota.
DR GeneTree; ENSGT00390000015492; -.
DR HOGENOM; CLU_160791_0_0_1; -.
DR InParanoid; Q61839; -.
DR OMA; HDYPNAR; -.
DR OrthoDB; 1491136at2759; -.
DR PhylomeDB; Q61839; -.
DR TreeFam; TF106305; -.
DR Reactome; R-MMU-5578768; Physiological factors.
DR BioGRID-ORCS; 18159; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q61839; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q61839; protein.
DR Bgee; ENSMUSG00000026241; Expressed in lumbar subsegment of spinal cord and 57 other tissues.
DR ExpressionAtlas; Q61839; baseline and differential.
DR Genevisible; Q61839; MM.
DR GO; GO:0005576; C:extracellular region; TAS:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; ISO:MGI.
DR GO; GO:0051427; F:hormone receptor binding; ISO:MGI.
DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR GO; GO:0048513; P:animal organ development; IMP:MGI.
DR GO; GO:0006182; P:cGMP biosynthetic process; IMP:GO_Central.
DR GO; GO:0019934; P:cGMP-mediated signaling; ISO:MGI.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; IMP:UniProtKB.
DR GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; IMP:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0032966; P:negative regulation of collagen biosynthetic process; ISO:MGI.
DR GO; GO:2000279; P:negative regulation of DNA biosynthetic process; ISO:MGI.
DR GO; GO:0051447; P:negative regulation of meiotic cell cycle; IMP:MGI.
DR GO; GO:1900194; P:negative regulation of oocyte maturation; IMP:MGI.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; ISO:MGI.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:MGI.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:MGI.
DR GO; GO:1900721; P:positive regulation of uterine smooth muscle relaxation; ISO:MGI.
DR GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR GO; GO:0006457; P:protein folding; ISO:MGI.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0022414; P:reproductive process; IMP:MGI.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR InterPro; IPR002406; C_natriurtcpep.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00713; CNATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone; Osteogenesis;
KW Reference proteome; Secreted; Signal; Vasoactive.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..73
FT /id="PRO_0000001557"
FT PEPTIDE 74..126
FT /note="CNP-53"
FT /evidence="ECO:0000250"
FT /id="PRO_0000001558"
FT PEPTIDE 98..126
FT /note="CNP-29"
FT /evidence="ECO:0000250"
FT /id="PRO_0000001559"
FT PEPTIDE 105..126
FT /note="CNP-22"
FT /id="PRO_0000001560"
FT REGION 20..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 110..126
FT /evidence="ECO:0000250"
SQ SEQUENCE 126 AA; 13320 MW; 8F65B1C4E82F0ACB CRC64;
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ KKGDKTPGSG
GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS
MSGLGC
