ANFC_RAT
ID ANFC_RAT Reviewed; 126 AA.
AC P55207;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=C-type natriuretic peptide;
DE Contains:
DE RecName: Full=CNP-22;
DE Contains:
DE RecName: Full=CNP-29;
DE Contains:
DE RecName: Full=CNP-53;
DE Flags: Precursor;
GN Name=Nppc; Synonyms=Cnp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1702395; DOI=10.1016/0014-5793(90)80544-s;
RA Kojima M., Minamino N., Kangawa K., Matsuo H.;
RT "Cloning and sequence analysis of a cDNA encoding a precursor for rat C-
RT type natriuretic peptide (CNP).";
RL FEBS Lett. 276:209-213(1990).
CC -!- FUNCTION: [CNP-22]: Hormone which plays a role in endochondral
CC ossification through regulation of cartilaginous growth plate
CC chondrocytes proliferation and differentiation (By similarity). May
CC also be vasoactive and natriuretic. Acts by specifically binding and
CC stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By
CC similarity). {ECO:0000250|UniProtKB:P23582,
CC ECO:0000250|UniProtKB:Q61839}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in brain.
CC -!- PTM: [CNP-22]: Degraded by IDE (in vitro).
CC {ECO:0000250|UniProtKB:P23582}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR EMBL; D90219; BAA14250.1; -; mRNA.
DR PIR; S12988; S12988.
DR RefSeq; NP_446202.1; NM_053750.1.
DR AlphaFoldDB; P55207; -.
DR STRING; 10116.ENSRNOP00000025582; -.
DR iPTMnet; P55207; -.
DR PhosphoSitePlus; P55207; -.
DR PaxDb; P55207; -.
DR PRIDE; P55207; -.
DR Ensembl; ENSRNOT00000025582; ENSRNOP00000025582; ENSRNOG00000018854.
DR GeneID; 114593; -.
DR KEGG; rno:114593; -.
DR UCSC; RGD:620850; rat.
DR CTD; 4880; -.
DR RGD; 620850; Nppc.
DR eggNOG; ENOG502S2QY; Eukaryota.
DR GeneTree; ENSGT00390000015492; -.
DR HOGENOM; CLU_160791_0_0_1; -.
DR InParanoid; P55207; -.
DR OMA; HDYPNAR; -.
DR OrthoDB; 1491136at2759; -.
DR PhylomeDB; P55207; -.
DR TreeFam; TF106305; -.
DR Reactome; R-RNO-5578768; Physiological factors.
DR PRO; PR:P55207; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000018854; Expressed in cerebellum and 11 other tissues.
DR Genevisible; P55207; RN.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0030141; C:secretory granule; IDA:RGD.
DR GO; GO:0005179; F:hormone activity; IDA:RGD.
DR GO; GO:0051427; F:hormone receptor binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0048513; P:animal organ development; ISO:RGD.
DR GO; GO:0006182; P:cGMP biosynthetic process; ISO:RGD.
DR GO; GO:0019934; P:cGMP-mediated signaling; IDA:RGD.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0032966; P:negative regulation of collagen biosynthetic process; IDA:RGD.
DR GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IDA:RGD.
DR GO; GO:0051447; P:negative regulation of meiotic cell cycle; ISO:RGD.
DR GO; GO:1900194; P:negative regulation of oocyte maturation; ISO:RGD.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IDA:RGD.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IDA:UniProtKB.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:RGD.
DR GO; GO:1900721; P:positive regulation of uterine smooth muscle relaxation; IDA:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; ISO:RGD.
DR GO; GO:0006457; P:protein folding; ISO:RGD.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IDA:MGI.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISO:RGD.
DR GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IEP:RGD.
DR GO; GO:0022414; P:reproductive process; ISO:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR InterPro; IPR002406; C_natriurtcpep.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00713; CNATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone; Osteogenesis;
KW Reference proteome; Secreted; Signal; Vasoactive.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..73
FT /id="PRO_0000001565"
FT PEPTIDE 74..126
FT /note="CNP-53"
FT /id="PRO_0000001566"
FT PEPTIDE 98..126
FT /note="CNP-29"
FT /evidence="ECO:0000250"
FT /id="PRO_0000001567"
FT PEPTIDE 105..126
FT /note="CNP-22"
FT /id="PRO_0000001568"
FT REGION 19..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 110..126
FT /evidence="ECO:0000250"
SQ SEQUENCE 126 AA; 13314 MW; 0957A0DB5BC82E08 CRC64;
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL AEPQAAGGNQ KKGDKTPGGG
GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS
MSGLGC
