ID   ANFC_SQUAC              Reviewed;         135 AA.
AC   P41319;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=C-type natriuretic peptide;
DE   Flags: Precursor;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=1928383; DOI=10.1152/ajprenal.1991.261.4.f734;
RA   Schofield J.P., Jones D.S.C., Forrest J.N. Jr.;
RT   "Identification of C-type natriuretic peptide in heart of spiny dogfish
RT   shark (Squalus acanthias).";
RL   Am. J. Physiol. 261:F734-F739(1991).
CC   -!- FUNCTION: Hormone which may be vasoactive and natriuretic. Has a cGMP-
CC       stimulating activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; X59991; CAA42608.1; -; mRNA.
DR   PIR; A61244; A61244.
DR   AlphaFoldDB; P41319; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal; Vasoactive.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..113
FT                   /id="PRO_0000001601"
FT   PEPTIDE         114..135
FT                   /note="C-type natriuretic peptide"
FT                   /id="PRO_0000001602"
FT   REGION          46..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        119..135
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  15062 MW;  BDA4FA25B63736CC CRC64;
     MSGHTSFYCG LLLLLLIQVQ ARPRADDSLQ VLSRLLEDEY GHFNSEELNN EAQEISPAAS
     LPDLNTDQSD LELPWDRESR EIGGRSFRQE ALLARLLQDL SNNPLRFKGR SKKGPSRSCF
     GLKLDRIGAM SGLGC