HDA_ECOL6
ID HDA_ECOL6 Reviewed; 233 AA.
AC P69932; P76570; P76979;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=c3013;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC Rule:MF_01158}.
CC -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01158}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN81463.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN81463.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001307333.1; NZ_CP051263.1.
DR AlphaFoldDB; P69932; -.
DR SMR; P69932; -.
DR STRING; 199310.c3013; -.
DR EnsemblBacteria; AAN81463; AAN81463; c3013.
DR GeneID; 66673639; -.
DR KEGG; ecc:c3013; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_072265_1_1_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01158; Hda; 1.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR017788; Hda.
DR InterPro; IPR022864; Hda_Enterobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00308; Bac_DnaA; 1.
DR PRINTS; PR00051; DNAA.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA replication inhibitor.
FT CHAIN 1..233
FT /note="DnaA regulatory inactivator Hda"
FT /id="PRO_0000114315"
SQ SEQUENCE 233 AA; 26633 MW; D25C7CDF31DAF7DC CRC64;
MNTPAQLSLP LYLPDDETFA SFWPGDNSSL LAALQNVLRQ EHSGYIYLWA REGAGRSHLL
HAACAELSQR GDAVGYVPLD KRTWFVPEVL DGMEHLSLVC IDNIECIAGD ELWEMAIFDL
YNRILESGKT RLLITGDRPP RQLNLGLPDL ASRLDWGQIY KLQPLSDEDK LQALQLRARL
RGFELPEDVG RFLLKRLDRE MRTLFMTLDQ LDRASITAQR KLTIPFVKEI LKL