ID   HDA_KLEP7               Reviewed;         225 AA.
AC   A6TCA8;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   OrderedLocusNames=KPN78578_27680; ORFNames=KPN_02819;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC       DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC       hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC       reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC       RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC       the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC       Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
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DR   EMBL; CP000647; ABR78229.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6TCA8; -.
DR   SMR; A6TCA8; -.
DR   STRING; 272620.KPN_02819; -.
DR   EnsemblBacteria; ABR78229; ABR78229; KPN_02819.
DR   KEGG; kpn:KPN_02819; -.
DR   HOGENOM; CLU_072265_1_1_6; -.
DR   OMA; DWGQIYR; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA replication inhibitor; Reference proteome.
FT   CHAIN           1..225
FT                   /note="DnaA regulatory inactivator Hda"
FT                   /id="PRO_0000389448"
SQ   SEQUENCE   225 AA;  25823 MW;  3A5C50A7E2BABC17 CRC64;
     MPLYLPDDET FASFWPGDNP SLLAALQNVL RQEHSGYIYI WSREGAGRSH LLHAACAELS
     QRGDAVGYVP LDKRTWFVPE VLEGMEQLAL VCIDNIECVA GDEPWEMAIF NLYNRILESG
     KTRLLITGDR PPRQLNLGLP DLASRLDWGQ IYKLQPLSDE DKLQALQLRA RLRGFEMPED
     VCRFLLKRLD REMRSLFMTL DQLDHASITA QRKLTIPFVK EILKL