HDA_SALA4
ID HDA_SALA4 Reviewed; 241 AA.
AC B5F171;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=SeAg_B2643;
OS Salmonella agona (strain SL483).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=454166;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL483;
RX PubMed=21602358; DOI=10.1128/jb.00297-11;
RA Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA Leclerc J.E., Ravel J., Cebula T.A.;
RT "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT CRISPR-mediated adaptive sublineage evolution.";
RL J. Bacteriol. 193:3556-3568(2011).
CC -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC Rule:MF_01158}.
CC -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01158}.
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DR EMBL; CP001138; ACH51188.1; -; Genomic_DNA.
DR RefSeq; WP_000100388.1; NC_011149.1.
DR AlphaFoldDB; B5F171; -.
DR SMR; B5F171; -.
DR EnsemblBacteria; ACH51188; ACH51188; SeAg_B2643.
DR KEGG; sea:SeAg_B2643; -.
DR HOGENOM; CLU_072265_1_1_6; -.
DR OMA; DWGQIYR; -.
DR Proteomes; UP000008819; Chromosome.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01158; Hda; 1.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR017788; Hda.
DR InterPro; IPR022864; Hda_Enterobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00308; Bac_DnaA; 1.
DR PRINTS; PR00051; DNAA.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA replication inhibitor.
FT CHAIN 1..241
FT /note="DnaA regulatory inactivator Hda"
FT /id="PRO_1000137816"
SQ SEQUENCE 241 AA; 27472 MW; F27B42EF7FAAA63E CRC64;
MSSWVEVSLN TPAQLSLPLY LPDDETFASF WPGDNASLLA ALQNVLRQEH SGYIYLWARE
GAGRSHLLHA ACAELSQRGD AVGYVPLDKR TWFVPEVLDG MEHLSLVCID NIECVAGDEL
WEMAIFDLYN RILESGKTRL LITGDRPPRQ LNLGLPDLAS RLDWGQIYKL QPLSDEDKLQ
ALQLRARLRG FELPEDVGRF LLKRLDREMR TLFMTLDQLD HASITAQRKL TIPFVKEILK
L