HDA_SALG2
ID HDA_SALG2 Reviewed; 241 AA.
AC B5RCW8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=SG2528;
OS Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=550538;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=287/91 / NCTC 13346;
RX PubMed=18583645; DOI=10.1101/gr.077404.108;
RA Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA Mungall K., Saunders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA Humphreys T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT gallinarum 287/91 provides insights into evolutionary and host adaptation
RT pathways.";
RL Genome Res. 18:1624-1637(2008).
CC -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC Rule:MF_01158}.
CC -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01158}.
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DR EMBL; AM933173; CAR38354.1; -; Genomic_DNA.
DR RefSeq; WP_000100388.1; NC_011274.1.
DR AlphaFoldDB; B5RCW8; -.
DR SMR; B5RCW8; -.
DR EnsemblBacteria; CAR38354; CAR38354; SG2528.
DR KEGG; seg:SG2528; -.
DR HOGENOM; CLU_072265_1_1_6; -.
DR OMA; DWGQIYR; -.
DR Proteomes; UP000008321; Chromosome.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01158; Hda; 1.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR017788; Hda.
DR InterPro; IPR022864; Hda_Enterobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00308; Bac_DnaA; 1.
DR PRINTS; PR00051; DNAA.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA replication inhibitor.
FT CHAIN 1..241
FT /note="DnaA regulatory inactivator Hda"
FT /id="PRO_1000137819"
SQ SEQUENCE 241 AA; 27472 MW; F27B42EF7FAAA63E CRC64;
MSSWVEVSLN TPAQLSLPLY LPDDETFASF WPGDNASLLA ALQNVLRQEH SGYIYLWARE
GAGRSHLLHA ACAELSQRGD AVGYVPLDKR TWFVPEVLDG MEHLSLVCID NIECVAGDEL
WEMAIFDLYN RILESGKTRL LITGDRPPRQ LNLGLPDLAS RLDWGQIYKL QPLSDEDKLQ
ALQLRARLRG FELPEDVGRF LLKRLDREMR TLFMTLDQLD HASITAQRKL TIPFVKEILK
L