ID   ANFD_LITCT              Reviewed;         118 AA.
AC   P40756;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=C-type natriuretic peptide 2;
DE   AltName: Full=CNP II;
DE   Flags: Precursor;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8175740; DOI=10.1016/s0021-9258(17)36809-6;
RA   Kojima M., Ohyama Y., Miyamoto K., Minamino N., Kangawa K., Matsuo H.;
RT   "Cloning and characterization of a novel natriuretic peptide in frog (Rana
RT   catesbeiana).";
RL   J. Biol. Chem. 269:13136-13140(1994).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressor activity. Has a cGMP-
CC       stimulating activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; D17414; BAA04236.1; -; mRNA.
DR   PIR; B54119; B54119.
DR   AlphaFoldDB; P40756; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal; Vasoactive.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..96
FT                   /id="PRO_0000001575"
FT   PEPTIDE         97..118
FT                   /note="C-type natriuretic peptide 2"
FT                   /id="PRO_0000001576"
FT   DISULFID        102..118
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   118 AA;  13136 MW;  F091C3C4AD707603 CRC64;
     MHFCHIVGWG LVLAVLYLRT EAKPVAQAHQ KSLRALLGEE LAEYLVSGER GERSIDPKTR
     ARLLRDIRAD TRSRAAWTRL LNEHPNSRKI KGINKKGTSK GCFGLKLDRI GAMSGLGC