ID   HDA_SALTY               Reviewed;         241 AA.
AC   Q7CQ21;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=STM2496;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC       DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC       hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC       reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC       RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC       the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC       Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
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DR   EMBL; AE006468; AAL21390.1; -; Genomic_DNA.
DR   RefSeq; NP_461431.1; NC_003197.2.
DR   RefSeq; WP_000100388.1; NC_003197.2.
DR   AlphaFoldDB; Q7CQ21; -.
DR   SMR; Q7CQ21; -.
DR   STRING; 99287.STM2496; -.
DR   PaxDb; Q7CQ21; -.
DR   EnsemblBacteria; AAL21390; AAL21390; STM2496.
DR   GeneID; 1254018; -.
DR   KEGG; stm:STM2496; -.
DR   PATRIC; fig|99287.12.peg.2634; -.
DR   HOGENOM; CLU_072265_1_1_6; -.
DR   OMA; DWGQIYR; -.
DR   PhylomeDB; Q7CQ21; -.
DR   BioCyc; SENT99287:STM2496-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA replication inhibitor; Reference proteome.
FT   CHAIN           1..241
FT                   /note="DnaA regulatory inactivator Hda"
FT                   /id="PRO_0000114320"
SQ   SEQUENCE   241 AA;  27472 MW;  F27B42EF7FAAA63E CRC64;
     MSSWVEVSLN TPAQLSLPLY LPDDETFASF WPGDNASLLA ALQNVLRQEH SGYIYLWARE
     GAGRSHLLHA ACAELSQRGD AVGYVPLDKR TWFVPEVLDG MEHLSLVCID NIECVAGDEL
     WEMAIFDLYN RILESGKTRL LITGDRPPRQ LNLGLPDLAS RLDWGQIYKL QPLSDEDKLQ
     ALQLRARLRG FELPEDVGRF LLKRLDREMR TLFMTLDQLD HASITAQRKL TIPFVKEILK
     L