ID   HDA_YERPA               Reviewed;         235 AA.
AC   Q1C5P5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=YPA_2262;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator protein
CC       DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates
CC       hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for
CC       reinitiation, a process called regulatory inhibition of DnaA or RIDA
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC       RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC       the DNA-loaded beta sliding clamp (dnaN). {ECO:0000255|HAMAP-
CC       Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
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DR   EMBL; CP000308; ABG14227.1; -; Genomic_DNA.
DR   RefSeq; WP_002228401.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1C5P5; -.
DR   SMR; Q1C5P5; -.
DR   EnsemblBacteria; ABG14227; ABG14227; YPA_2262.
DR   GeneID; 66844784; -.
DR   KEGG; ypa:YPA_2262; -.
DR   OMA; DWGQIYR; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA replication inhibitor.
FT   CHAIN           1..235
FT                   /note="DnaA regulatory inactivator Hda"
FT                   /id="PRO_1000065571"
SQ   SEQUENCE   235 AA;  26703 MW;  4D4CB860F7C0D573 CRC64;
     MLLNTPAQLS LPLYLPDDET FASFYPGENP SLLAAIQSAV HQPHGSYIYF WSREGGGRSH
     LLHAACAELS QQGEAVGYVP LDKRAYFIPE VLEGMEQLAL VCIDNIECIA GDEQWEMAMF
     NLYNRIVETG RTRLLITGDR PPRQLNLGLP DLASRLDWGQ IYKLQPLSDD EKLQALQLRA
     KLRGFELPED VGRFLLKRLD REMRTLFMTL DQLDRASITA QRKLTIPFVK EILSL