ID   HDC_HUMAN               Reviewed;         543 AA.
AC   Q9UBI9;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Headcase protein homolog;
DE            Short=hHDC;
GN   Name=HECA; Synonyms=HDC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|EMBL:CAB94782.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP   CHROMOSOMAL LOCATION.
RX   PubMed=11696983; DOI=10.3109/10425170109041340;
RA   Makino N., Yamato T., Inoue H., Furukawa T., Abe T., Yokoyama T.,
RA   Yatsuoka T., Fukushige S., Orikasa S., Takahashi T., Horii A.;
RT   "Isolation and characterization of the human gene homologous to the
RT   Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of
RT   common deletion in human pancreatic cancer.";
RL   DNA Seq. 11:547-553(2001).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-268, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-268, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
CC   -!- FUNCTION: May play an important role in some human cancers. May be part
CC       of the regulatory mechanism in the development of epithelial tube
CC       networks such as the circulatory system and lungs.
CC       {ECO:0000303|PubMed:11696983}.
CC   -!- TISSUE SPECIFICITY: Expressed in all tissues examined. Highest levels
CC       are in the spleen, thymus, peripheral blood and heart. Lowest in the
CC       kidney and pancreas. {ECO:0000269|PubMed:11696983}.
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DR   EMBL; AB033496; BAA85333.1; -; Genomic_DNA.
DR   EMBL; AB033492; BAA85322.1; -; mRNA.
DR   EMBL; AL031772; CAB94782.1; -; Genomic_DNA.
DR   EMBL; BC070068; AAH70068.1; -; mRNA.
DR   CCDS; CCDS5194.1; -.
DR   RefSeq; NP_057301.1; NM_016217.2.
DR   AlphaFoldDB; Q9UBI9; -.
DR   BioGRID; 119682; 9.
DR   STRING; 9606.ENSP00000356630; -.
DR   GlyGen; Q9UBI9; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q9UBI9; -.
DR   PhosphoSitePlus; Q9UBI9; -.
DR   BioMuta; HECA; -.
DR   DMDM; 44887986; -.
DR   EPD; Q9UBI9; -.
DR   jPOST; Q9UBI9; -.
DR   MassIVE; Q9UBI9; -.
DR   MaxQB; Q9UBI9; -.
DR   PaxDb; Q9UBI9; -.
DR   PeptideAtlas; Q9UBI9; -.
DR   PRIDE; Q9UBI9; -.
DR   ProteomicsDB; 83976; -.
DR   Antibodypedia; 33083; 69 antibodies from 15 providers.
DR   DNASU; 51696; -.
DR   Ensembl; ENST00000367658.3; ENSP00000356630.2; ENSG00000112406.5.
DR   GeneID; 51696; -.
DR   KEGG; hsa:51696; -.
DR   MANE-Select; ENST00000367658.3; ENSP00000356630.2; NM_016217.3; NP_057301.1.
DR   UCSC; uc003qin.4; human.
DR   CTD; 51696; -.
DR   DisGeNET; 51696; -.
DR   GeneCards; HECA; -.
DR   HGNC; HGNC:21041; HECA.
DR   HPA; ENSG00000112406; Low tissue specificity.
DR   MIM; 607977; gene.
DR   neXtProt; NX_Q9UBI9; -.
DR   OpenTargets; ENSG00000112406; -.
DR   PharmGKB; PA134977625; -.
DR   VEuPathDB; HostDB:ENSG00000112406; -.
DR   eggNOG; KOG3816; Eukaryota.
DR   GeneTree; ENSGT00500000044928; -.
DR   HOGENOM; CLU_027672_0_0_1; -.
DR   InParanoid; Q9UBI9; -.
DR   OMA; KNEAPCA; -.
DR   OrthoDB; 1215307at2759; -.
DR   PhylomeDB; Q9UBI9; -.
DR   TreeFam; TF315512; -.
DR   PathwayCommons; Q9UBI9; -.
DR   SignaLink; Q9UBI9; -.
DR   BioGRID-ORCS; 51696; 11 hits in 1079 CRISPR screens.
DR   ChiTaRS; HECA; human.
DR   GenomeRNAi; 51696; -.
DR   Pharos; Q9UBI9; Tbio.
DR   PRO; PR:Q9UBI9; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9UBI9; protein.
DR   Bgee; ENSG00000112406; Expressed in amniotic fluid and 212 other tissues.
DR   Genevisible; Q9UBI9; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:HGNC.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:HGNC.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:HGNC.
DR   GO; GO:0030323; P:respiratory tube development; NAS:UniProtKB.
DR   InterPro; IPR026066; Headcase.
DR   InterPro; IPR031947; Headcase_mid.
DR   PANTHER; PTHR13425; PTHR13425; 1.
DR   Pfam; PF16002; Headcase; 1.
DR   Pfam; PF15353; HECA; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Phosphoprotein; Reference proteome.
FT   CHAIN           1..543
FT                   /note="Headcase protein homolog"
FT                   /id="PRO_0000083934"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         264
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18669648,
FT                   ECO:0007744|PubMed:19690332"
FT   MOD_RES         268
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18669648,
FT                   ECO:0007744|PubMed:19690332"
SQ   SEQUENCE   543 AA;  58837 MW;  A161B7F4C57EF0D1 CRC64;
     MPNPKNSKGG RKNKRANSSG DEQENGAGAL AAAGAAGAAA GGALAAAAGC GAAAAGAPGA
     GGAAGAGGAG TGAANAAAAA GAAAAGDAKN EAPCATPLIC SFGRPVDLEK DDYQKVVCNN
     EHCPCSTWMH LQCFYEWESS ILVQFNCIGR ARSWNEKQCR QNMWTKKGYD LAFRFCSCRC
     GQGHLKKDTD WYQVKRMQDE KKKKSGSEKN TGRPPGEAAE EAKKCRPPNK PQKGPSHDLP
     RRHSMDRQNS QEKAVGAAAY GARSPGGSPG QSPPTGYSIL SPAHFSGPRS SRYLGEFLKN
     AIHLEPHKKA MAGGHVFRNA HFDYSPAGLA VHRGGHFDTP VQFLRRLDLS ELLTHIPRHK
     LNTFHVRMED DAQVGQGEDL RKFILAALSA SHRNVVNCAL CHRALPVFEQ FPLVDGTLFL
     SPSRHDEIEY DVPCHLQGRL MHLYAVCVDC LEGVHKIICI KCKSRWDGSW HQLGTMYTYD
     ILAASPCCQA RLNCKHCGKP VIDVRIGMQY FSEYSNVQQC PHCGNLDYHF VKPFSSFKVL
     EAY