HDEA_BRUAB
ID HDEA_BRUAB Reviewed; 114 AA.
AC Q577F1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Probable acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule:MF_00946};
DE Flags: Precursor;
GN Name=hdeA {ECO:0000255|HAMAP-Rule:MF_00946}; OrderedLocusNames=BruAb2_0840;
OS Brucella abortus biovar 1 (strain 9-941).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=262698;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9-941;
RX PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT "Completion of the genome sequence of Brucella abortus and comparison to
RT the highly similar genomes of Brucella melitensis and Brucella suis.";
RL J. Bacteriol. 187:2715-2726(2005).
CC -!- FUNCTION: Required for optimal acid stress protection. Exhibits a
CC chaperone-like activity only at low pH by suppressing non-specifically
CC the aggregation of denaturated periplasmic proteins.
CC {ECO:0000255|HAMAP-Rule:MF_00946}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946}.
CC -!- SIMILARITY: Belongs to the HdeA family. {ECO:0000255|HAMAP-
CC Rule:MF_00946}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017224; AAX76233.1; -; Genomic_DNA.
DR RefSeq; WP_002966248.1; NC_006933.1.
DR AlphaFoldDB; Q577F1; -.
DR SMR; Q577F1; -.
DR EnsemblBacteria; AAX76233; AAX76233; BruAb2_0840.
DR GeneID; 3828246; -.
DR GeneID; 55592038; -.
DR KEGG; bmb:BruAb2_0840; -.
DR HOGENOM; CLU_170142_0_0_5; -.
DR OMA; ACTENKK; -.
DR PRO; PR:Q577F1; -.
DR Proteomes; UP000000540; Chromosome II.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.890.10; -; 1.
DR HAMAP; MF_00946; HdeA; 1.
DR InterPro; IPR024972; HdeA.
DR InterPro; IPR038303; HdeA/HdeB_sf.
DR InterPro; IPR036831; HdeA_sf.
DR InterPro; IPR010486; HNS-dep_expression_A/B.
DR Pfam; PF06411; HdeA; 1.
DR PIRSF; PIRSF009564; HNS-dep_expression_A; 1.
DR SUPFAM; SSF47752; SSF47752; 1.
PE 3: Inferred from homology;
KW Chaperone; Disulfide bond; Periplasm; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
FT CHAIN 27..114
FT /note="Probable acid stress chaperone HdeA"
FT /id="PRO_0000338632"
FT DISULFID 46..94
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
SQ SEQUENCE 114 AA; 12332 MW; 0B5A298253466C53 CRC64;
MIKALFNKNT ALAAVAILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV
VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF