ID   HDEA_BRUC2              Reviewed;         114 AA.
AC   A9ME89;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Probable acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule:MF_00946};
DE   Flags: Precursor;
GN   Name=hdeA {ECO:0000255|HAMAP-Rule:MF_00946}; OrderedLocusNames=BCAN_B0343;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for optimal acid stress protection. Exhibits a
CC       chaperone-like activity only at low pH by suppressing non-specifically
CC       the aggregation of denaturated periplasmic proteins.
CC       {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SIMILARITY: Belongs to the HdeA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00946}.
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DR   EMBL; CP000873; ABX63527.1; -; Genomic_DNA.
DR   RefSeq; WP_002966248.1; NC_010104.1.
DR   AlphaFoldDB; A9ME89; -.
DR   SMR; A9ME89; -.
DR   EnsemblBacteria; ABX63527; ABX63527; BCAN_B0343.
DR   GeneID; 3828246; -.
DR   GeneID; 55592038; -.
DR   KEGG; bcs:BCAN_B0343; -.
DR   HOGENOM; CLU_170142_0_0_5; -.
DR   OMA; ACTENKK; -.
DR   PhylomeDB; A9ME89; -.
DR   Proteomes; UP000001385; Chromosome II.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.890.10; -; 1.
DR   HAMAP; MF_00946; HdeA; 1.
DR   InterPro; IPR024972; HdeA.
DR   InterPro; IPR038303; HdeA/HdeB_sf.
DR   InterPro; IPR036831; HdeA_sf.
DR   InterPro; IPR010486; HNS-dep_expression_A/B.
DR   Pfam; PF06411; HdeA; 1.
DR   PIRSF; PIRSF009564; HNS-dep_expression_A; 1.
DR   SUPFAM; SSF47752; SSF47752; 1.
PE   3: Inferred from homology;
KW   Chaperone; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
FT   CHAIN           27..114
FT                   /note="Probable acid stress chaperone HdeA"
FT                   /id="PRO_0000338633"
FT   DISULFID        46..94
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
SQ   SEQUENCE   114 AA;  12332 MW;  0B5A298253466C53 CRC64;
     MIKALFNKNT ALAAVAILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV
     VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF