ID   HDEA_BRUME              Reviewed;         114 AA.
AC   Q8YBJ4; Q6R2J7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Probable acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule:MF_00946};
DE   Flags: Precursor;
GN   Name=hdeA {ECO:0000255|HAMAP-Rule:MF_00946}; OrderedLocusNames=BMEII0906;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Rev.1;
RA   Baum M., Hahn H., Splitter G.A., Mielke M., Bernstein M., Bardenstein S.,
RA   Osman F., Ben-Asuli Y., Gaathon A., Molad T., Stram Y., Banai M.;
RT   "Gene and protein annotation of the Brucella melitensis 10kDa protein as an
RT   E. coli HdeA type II secretion homolog inducing CD8 T-cell subtype immune
RT   cells in Rev.1 vaccinated guinea pigs.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Required for optimal acid stress protection. Exhibits a
CC       chaperone-like activity only at low pH by suppressing non-specifically
CC       the aggregation of denaturated periplasmic proteins.
CC       {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946}.
CC   -!- SIMILARITY: Belongs to the HdeA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00946}.
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DR   EMBL; AY518304; AAR98497.1; -; Genomic_DNA.
DR   EMBL; AE008918; AAL54148.1; -; Genomic_DNA.
DR   PIR; AI3622; AI3622.
DR   RefSeq; WP_002966248.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YBJ4; -.
DR   SMR; Q8YBJ4; -.
DR   STRING; 224914.BMEII0906; -.
DR   EnsemblBacteria; AAL54148; AAL54148; BMEII0906.
DR   GeneID; 3828246; -.
DR   GeneID; 55592038; -.
DR   KEGG; bme:BMEII0906; -.
DR   PATRIC; fig|224914.52.peg.2455; -.
DR   eggNOG; ENOG5032Y4G; Bacteria.
DR   PhylomeDB; Q8YBJ4; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.890.10; -; 1.
DR   HAMAP; MF_00946; HdeA; 1.
DR   InterPro; IPR024972; HdeA.
DR   InterPro; IPR038303; HdeA/HdeB_sf.
DR   InterPro; IPR036831; HdeA_sf.
DR   InterPro; IPR010486; HNS-dep_expression_A/B.
DR   Pfam; PF06411; HdeA; 1.
DR   PIRSF; PIRSF009564; HNS-dep_expression_A; 1.
DR   SUPFAM; SSF47752; SSF47752; 1.
PE   3: Inferred from homology;
KW   Chaperone; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
FT   CHAIN           27..114
FT                   /note="Probable acid stress chaperone HdeA"
FT                   /id="PRO_0000338634"
FT   DISULFID        46..94
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
SQ   SEQUENCE   114 AA;  12332 MW;  0B5A298253466C53 CRC64;
     MIKALFNKNT ALAAVAILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV
     VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF