HDEA_BRUSI
ID HDEA_BRUSI Reviewed; 114 AA.
AC A9WY36;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Probable acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule:MF_00946};
DE Flags: Precursor;
GN Name=hdeA {ECO:0000255|HAMAP-Rule:MF_00946}; OrderedLocusNames=BSUIS_B0347;
OS Brucella suis (strain ATCC 23445 / NCTC 10510).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=470137;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23445 / NCTC 10510;
RA Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA Bruce D., Detter C., Munk C., Brettin T.S.;
RT "Brucella suis ATCC 23445 whole genome shotgun sequencing project.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for optimal acid stress protection. Exhibits a
CC chaperone-like activity only at low pH by suppressing non-specifically
CC the aggregation of denaturated periplasmic proteins.
CC {ECO:0000255|HAMAP-Rule:MF_00946}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946}.
CC -!- SIMILARITY: Belongs to the HdeA family. {ECO:0000255|HAMAP-
CC Rule:MF_00946}.
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DR EMBL; CP000912; ABY39352.1; -; Genomic_DNA.
DR RefSeq; WP_002966248.1; NC_010167.1.
DR AlphaFoldDB; A9WY36; -.
DR SMR; A9WY36; -.
DR EnsemblBacteria; ABY39352; ABY39352; BSUIS_B0347.
DR GeneID; 3828246; -.
DR GeneID; 55592038; -.
DR KEGG; bmt:BSUIS_B0347; -.
DR HOGENOM; CLU_170142_0_0_5; -.
DR OMA; ACTENKK; -.
DR Proteomes; UP000008545; Chromosome II.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:1990451; P:cellular stress response to acidic pH; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.890.10; -; 1.
DR HAMAP; MF_00946; HdeA; 1.
DR InterPro; IPR024972; HdeA.
DR InterPro; IPR038303; HdeA/HdeB_sf.
DR InterPro; IPR036831; HdeA_sf.
DR InterPro; IPR010486; HNS-dep_expression_A/B.
DR Pfam; PF06411; HdeA; 1.
DR PIRSF; PIRSF009564; HNS-dep_expression_A; 1.
DR SUPFAM; SSF47752; SSF47752; 1.
PE 3: Inferred from homology;
KW Chaperone; Disulfide bond; Periplasm; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
FT CHAIN 27..114
FT /note="Probable acid stress chaperone HdeA"
FT /id="PRO_0000338636"
FT DISULFID 46..94
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00946"
SQ SEQUENCE 114 AA; 12332 MW; 0B5A298253466C53 CRC64;
MIKALFNKNT ALAAVAILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV
VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF